Извор странице RFC3

{{PBB|geneid=5983}}
'''Репликациони фактор Ц, подјединица 3''' је [[протеин]] који је код људи кодиран'' RFC3'' [[ген]]ом<ref name="pmid7774928">{{cite journal |author1=Okumura K |author2=Nogami M |author3=Taguchi H |author4=Dean FB |author5=Chen M |author6=Pan ZQ |author7=Hurwitz J |author8=Shiratori A |author9=Murakami Y |author10=Ozawa K |display-authors=etal | title = Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23 | journal = Genomics | volume = 25 | issue = 1 | pages = 274–8 |date=јул 1995 | pmid = 7774928 | pmc =  | doi =10.1016/0888-7543(95)80135-9  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFC3 replication factor C (activator 1) 3, 38kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5983| accessdate = }}</ref>.

За елонгацију [[Прајмер (молекуларна биологија)|прајмираног]] ДНК шаблона [[ДНК полимераза делта|ДНК полимеразе делта]] и ДНК полимеразе епсилон неопходни су помоћни протеини: [[пролиферативни ћелијски нуклеарни антиген]] (PCNA) и [[репликациони фактор Ц]] (РФЦ). РФЦ, такође познат као активатор 1, је протеински комплекс који се састоји од пет подјединица са 140, 40, 38, 37, и 36 kDa. Овај ген кодира 38 кДа подједницу. Та подјединица је есенцијална за интеракцију између 140 kDа подјединице и сржи комплекса која се састоји од 36, 37, и 40 kDa подјединица. Познате су [[Алтернативно сплајсовања|алтернативно сплајсоване]] трансцриптне варијанте које кодирају различите [[Изоформа|изоформе]]<ref name="entrez" />.

== Интеракције ==
RFC3 формира [[Протеин-протеин интеракција|интеракције]] са [[BRD4]],<ref name="pmid12192049">{{cite journal |doi=10.1128/MCB.22.18.6509-6520.2002 |last=Maruyama |first=Tetsuo |author2=Farina Andrea |display-authors=etal |date= 2002 |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase |journal=Mol. Cell. Biol. |volume=22 |issue=18 |pages=6509–20 |publisher= |location = United States| issn = 0270-7306| pmid = 12192049 | bibcode = | oclc =| id = | url =https://archive.org/details/sim_molecular-and-cellular-biology_2002-09_22_18/page/6509| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=135621 }}</ref> [[CHTF18]],<ref name="pmid12930902">{{cite journal |last=Bermudez |first=Vladimir P |author2=Maniwa Yoshimasa |display-authors=etal |date= 2003 |title=The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=100 |issue=18 |pages=10237–42 |publisher= |location = United States| issn = 0027-8424| pmid = 12930902 |doi = 10.1073/pnas.1434308100 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=193545 }}</ref><ref name="pmid12766176">{{cite journal |last=Merkle |first=Carolin J |author2=Karnitz Larry M |display-authors=etal |date= 2003 |title=Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment |journal=J. Biol. Chem. |volume=278 |issue=32 |pages=30051–6 |publisher= |location = United States| issn = 0021-9258| pmid = 12766176 |doi = 10.1074/jbc.M211591200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[RFC1]],<ref name="pmid9488738">{{cite journal |doi=10.1074/jbc.273.10.5979 |last=Ellison |first=V |author2=Stillman B |date= 1998 |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity |journal=J. Biol. Chem. |volume=273 |issue=10 |pages=5979–87 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9488738 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name="pmid8692848">{{cite journal |doi=10.1073/pnas.93.13.6521 |last=Uhlmann |first=F |author2=Cai J |display-authors=etal |date= 1996 |title=In vitro reconstitution of human replication factor C from its five subunits |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=13 |pages=6521–6 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8692848 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=39056 }}</ref><ref name="pmid18245774">{{cite journal |last=Tomida |first=Junya |author2=Masuda Yuji |display-authors=etal |date= 2008 |title=DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex |journal=J. Biol. Chem. |volume=283 |issue=14 |pages=9071–9 |publisher= |location = United States| issn = 0021-9258| pmid = 18245774 |doi = 10.1074/jbc.M709835200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2431014 }}</ref> [[PCNA]]<ref name="pmid12766176"/><ref name="pmid12171929">{{cite journal |last=Ohta |first=Satoshi |author2=Shiomi Yasushi |display-authors=etal |date= 2002 |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein |journal=J. Biol. Chem. |volume=277 |issue=43 |pages=40362–7 |publisher= |location = United States| issn = 0021-9258| pmid = 12171929 |doi = 10.1074/jbc.M206194200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> i [[RFC4]].<ref name="pmid9488738"/><ref name="pmid8692848"/>

== Референце ==
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== Литература ==
{{Литература | 2}}
{{PBB_Further_reading 
| citations = 
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*{{cite journal  |vauthors=Ellison V, Stillman B |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5979–87 |year= 1998 |pmid= 9488738 |doi=10.1074/jbc.273.10.5979  }}
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}}
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