Извор странице Psilocibin

{{drugbox-lat | verifiedrevid = 408970911
| IUPAC_name = [3-(2-dimetilaminoetil)-1-{''H''}--indol-4-il] dihidrogen fosfat
| image = Psilocybin, Kekulé, skeletal formula of canonical psilocybin.svg
| image2 = Psilocybin3d.png
| width2 =
| width=200
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = C07576
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 194378
| DrugBank_Ref =
| DrugBank =
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C12H17N2O4P/c1-14(2)7-6-9-8-13-10-4-3-5-11(12(9)10)18-19(15,16)17/h3-5,8,13H,6-7H2,1-2H3,(H2,15,16,17)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = QVDSEJDULKLHCG-UHFFFAOYSA-N
| CAS_number_Ref = {{cascite|correct|}}
| CAS_number = 520-52-5
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10178
| ATC_prefix = none
| ATC_suffix =
| PubChem = 10624
| IUPHAR_ligand =
| C=12 | H=17 | N=2 | O=4 | P=1
| molecular_weight = 284,25 -{g/mol}-
| smiles = O=P(O)(O)Oc1cccc2c1c(cn2)CCN(C)C
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_AU =
| pregnancy_US =
| pregnancy_category =
| legal_AU = S9
| legal_CA = Schedule III
| legal_UK = Class A
| legal_US = Schedule I
| legal_status =
| routes_of_administration =
}}
'''Psilocibin''' (ili ''-{4-PO-DMT}-'') je [[halucinogeni]] sastojak prisutan u velikom broju [[gljive|gljiva]] iz roda -{''Psilocybe''}-, koje se u žarogonu zovu [[magične gljive]].<ref name="Beck1998">{{cite journal |vauthors=Beck O, Helander A, Karlson-Stiber C, Stephansson N |title=Presence of phenylethylamine in hallucinogenic ''Psilocybe'' mushroom: possible role in adverse reactions |journal=Journal of Analytical Toxicology |volume=22 |issue=1 |year=1998|pmid=9491968|pages=45-9}}</ref> U nekim plemenskim kulturama gljive se uživaju u religiozno-mistične svrhe. Danas je uživanje psilociba, iako u nekim zemljama nezakonito, sve više rasprostranjeno u zapadnom svetu.

''Psilocibin'' je izuzetno aktivna materija.<ref name="Abramson1965">{{cite journal |vauthors=Abramson HA, Rolo A |title=Lysergic acid diethylamide (LSD-25). 38. Comparison with action of methysergide and psilocybin on test subjects |journal=The Journal of Asthma Research |volume=3 |issue=1 |year=1965|pmid=5318626 |doi=10.3109/02770906509106904|pages=81-96}}</ref><ref name="Adams2009">{{cite journal |author=Adams JD Jr. |title=Chemical Interactions with pyramidal neurons in layer 5 of the cerebral cortex: control of pain and anxiety |journal=Current Medicinal Chemistry |year=2009|volume=16 |issue=27 |doi=10.2174/092986709789057626 |pmid=19799545|pages=3476-9}}</ref> Efekti psilocibina se porede sa efektima [[Диетиламид лисергинске киселине|LSD]]-a, samo kraćeg trajanja. Prvi efekti se javljaju već pri dozi od 0,5 grama osušenih gljiva. Simptomi nastaju 30min - 1 časa nakon konzumacije, a sastoje se od iznenadne zbunjenosti, mišićne slabosti, usporenja pulsa i sniženja krvnog pritiska i psihoznih efekata koji mogu biti ugodni, ali i neugodni. Pojavljuju se [[halucinacija]] i poremećaj percepcije vremena i prostora a nekad i [[euforija]] ili [[depresija]]. Efekti obično traju 4 do 6 časova.

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{Cite book | ref= harv|author=Boire RG. |title=Sacred Mushrooms and the Law |year=2002|publisher=Ronin Publishing |location=Berkeley, California |isbn=978-1579510619}}
* {{cite journal |author=Doblin R. |title=Pahnke's "Good Friday Experiment": A long-term follow-up and methodological critique |journal=Journal of Transpersonal Psychology |year=1991 |volume=23 |issue=1 |url=http://www.neurosoup.com/pdf/doblin_goodfriday_followup.pdf |format=PDF |pages=1-25 |access-date=14. 07. 2011 |archive-url=https://web.archive.org/web/20120816055955/http://www.neurosoup.com/pdf/doblin_goodfriday_followup.pdf |archive-date=16. 08. 2012 |url-status=dead |df= }}
* {{Cite book | ref= harv|author=Marley G. |chapter=Chapter 13. Psilocybin: Gateway to the Soul or Just a Good High? |title=Chanterelle Dreams, Amanita Nightmares: The Love, Lore, and Mystique of Mushrooms | url= https://archive.org/details/chanterelledream0000marl|publisher=Chelsea Green Publishing |location=White River Junction, Vermont |year=2010|isbn=978-1-60358-214-8|pages=[https://archive.org/details/chanterelledream0000marl/page/163 163]-84}}
* {{Cite book | ref= harv|author=Ott J. |title=Pharmacotheon Entheogenic Drugs Their Plant Sources and Histories |year=1993|publisher=Natural Products Company |location=Kennewick, Washington |isbn=978-0961423438}}
* {{Cite book | ref= harv|author=Stafford PJ. |title=Psychedelics Encyclopedia | url= https://archive.org/details/psychedelicsency0000staf_3ed|publisher=Ronin Publishing |location=Berkeley, California |year=1992|isbn=978-0-914171-51-5}}
* {{Cite book | ref= harv|author=Stamets P. |title=Psilocybin Mushrooms of the World: An Identification Guide | url= https://archive.org/details/psilocybinmushro0000stam|publisher=Ten Speed Press |location=Berkeley, California |year=1996|isbn=978-0-89815-839-7}}

=== 2006 Džon Hopkinsovi eksperimenti ===
-{
* [https://web.archive.org/web/20110730045114/http://www.hopkinsmedicine.org/press_releases/2006/07_11_06.html "Hopkins Scientists Show Hallucinogen in Mushrooms Creates Universal 'Mystical' Experience"], ''Johns Hopkins Medicine'' news release, July 11, 2006.
* [https://web.archive.org/web/20110716065016/http://www.hopkinsmedicine.org/Press_releases/2006/GriffithspsilocybinQ "Q&A is with Roland Griffiths, the study’s lead researcher"], ''Johns Hopkins Medicine'' news release, July 11, 2006.
* [http://www.medpagetoday.com/Psychiatry/GeneralPsychiatry/tb/3721 "Psilocybin Viewed as Therapy or Research Tool"] by Michael Smith, ''Medpagetoday.com'', July 12, 2006.
* [http://www.newscientist.com/article/dn9522-magic-mushrooms-really-cause-spiritual-experiences.html "Magic mushrooms really cause 'spiritual' experiences"] by Roxanne Khamsi, ''New Scientist news service'', July 11, 2006.
* [http://www.washingtonpost.com/wp-dyn/content/article/2006/07/10/AR2006071001304.html "Drug's Mystical Properties Confirmed"] by David Brown, ''Washington Post'', July 11, 2006.
* [http://www.nytimes.com/aponline/us/AP-Psychedelic-Research.html "Mushroom Drug Produces Mystical Experience"], ''Associated Press'', July 11, 2006.
* [http://www.latimes.com/news/science/la-sci-mystical11jul11,0,3028620.story?coll=la-home-headlines "Counterculture Drug Provides Spiritual Boost"] by Denise Gellene, ''Los Angeles Times'', July 11, 2006.
* [http://abcnews.go.com/Health/story?id=2174998&page=1 "Tripping Out: Scientists Study Mystical Effects of Mushrooms"] by Joy Victory, Bharathi Radhakrishnan, and Andrea Carter, ''ABC News'' (online), July 11, 2006. ABC News [https://web.archive.org/web/20181215224902/http://www.yoism.org/?q=node%2F219#GodPill video report of the study.]
}-
=== 2008 Nastavak Džon Hopkinsovih eksperimenta ===
-{
* [https://web.archive.org/web/20091113135946/http://sciencenow.sciencemag.org/cgi/content/full/2008/701/1 "A Very Memorable Trip"], by Greg Miller, ''ScienceNOW Daily News,'' July 1, 2008
* [https://web.archive.org/web/20110610041222/http://www.hopkinsmedicine.org/Press_releases/2008/07_01_08.html "Spiritual Effects of Hallucinogens Persist, Johns Hopkins Researchers Report"], ''Johns Hopkins Medicine'' news release, July 1, 2008.
* [http://www.wired.com/wiredscience/2008/07/psilocybin-stud/ "Psilocybin Study Hints at Rebirth of Hallucinogen Research"], by Brandon Keim, "Wired," July 1, 2008
* [https://web.archive.org/web/20110514042811/http://www2.citypaper.com/news/story.asp?id=16826 "Sacred Intentions: Inside the Johns Hopkins Psilocybin Studies"] by Michael M. Hughes, ''Baltimore City Paper'', October 8, 2008.
}- {{Литература крај}}

== Spoljašnje veze ==


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{{СОРТИРАЊЕ:Псилоцибин}}
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