Извор странице OPN3

{{PBB|geneid=23596}}
-{'''OPN3'''}-, ili ''Opsin-3'', je [[protein]] koji je kod čoveka kodiran -{''OPN3''}- [[gen]]om.<ref name="pmid10234000">{{cite journal |vauthors=Blackshaw S, Snyder SH | title = Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain | journal = J Neurosci | volume = 19 | issue = 10 | pages = 3681–90 | year = 1999 | pmid = 10234000 | pmc =  | doi =  }}</ref><ref name="pmid11401433">{{cite journal |vauthors=Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, Foster RG, Hunt DM | title = Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43 | journal = Genomics | volume = 72 | issue = 2 | pages = 203–8 | year = 2001 | pmid = 11401433 | pmc =  | doi = 10.1006/geno.2001.6469 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OPN3 opsin 3 (encephalopsin, panopsin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23596| accessdate = }}</ref> [[Alternativno splajsovanje]] ovog gena proizvodi više [[transkripcija (genetika)|transkriptnih]] varijanti, koje kodiraju različite [[proteinska izoforma|proteinske izoforme]].

== Funkcija ==

[[Opsin]]i su članovi familije [[G protein spregnuti receptori|G protein-spregnutih receptora]]. Osim vizuelnih opsina, sisari poseduje nekoliko [[fotoreceptorski protein|fotoreceptivnih]] ne-vizuelnih opsina koji su izraženi u tkivima izvan oka. Gen opsina-3 je u znatnoj meri izražen u mozgu i [[testis]]ima, a u maloj meri i u [[jetra|jetri]], [[materica|materici]], [[srce|srcu]], [[pluća|plućima]], skeletalnim mišima, [[bubreg|bubrezima]], i [[pankreas]]u. Ovaj gene isto tako može da bude izražen u [[mrežnjača|mrežnjači]]. Ovaj protein poseduje kanoničke osobine fotoreceptivnih opsina.<ref name="entrez" />

==Literatura==
{{reflist|2}}

==Dodatna literatura==
{{Литература | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |author1=Bonaldo MF |author2=Lennon G |author3=Soares MB   }}
*{{cite journal |title=Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids. |journal=Cytogenet. Cell Genet. |volume=95 |issue= 3-4 |pages= 234–5 |year= 2002 |pmid= 12063405 |doi=10.1159/000059351 |display-authors=3 |author1=Halford S |author2=Bellingham J |author3=Ocaka L  |last4=Fox |first4=M |last5=Johnson |first5=S |last6=Foster |first6=RG |last7=Hunt |first7=DM  }}
*{{cite journal |title=Different structural organization of the encephalopsin gene in man and mouse. |journal=Gene |volume=295 |issue= 1 |pages= 27–32 |year= 2003 |pmid= 12242008 |doi=10.1016/S0378-1119(02)00799-0 |display-authors=3 |author1=Kasper G |author2=Taudien S |author3=Staub E  |last4=Mennerich |first4=D |last5=Rieder |first5=M |last6=Hinzmann |first6=B |last7=Dahl |first7=E |last8=Schwidetzky |first8=U |last9=Rosenthal |first9=A  }}
*{{cite journal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |display-authors=3 |author1=Strausberg RL |author2=Feingold EA |author3=Grouse LH  |last4=Derge |first4=JG |last5=Klausner |first5=RD |last6=Collins |first6=FS |last7=Wagner |first7=L |last8=Shenmen |first8=CM |last9=Schuler |first9=GD |pmc=139241 }}
*{{cite journal |title=Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability. |journal=Cancer Genet. Cytogenet. |volume=147 |issue= 2 |pages= 121–7 |year= 2004 |pmid= 14623461 |doi=10.1016/S0165-4608(03)00196-1 |display-authors=3 |author1=Alam NA |author2=Gorman P |author3=Jaeger EE  |last4=Kelsell |first4=D |last5=Leigh |first5=IM |last6=Ratnavel |first6=R |last7=Murdoch |first7=ME |last8=Houlston |first8=RS |last9=Aaltonen |first9=LA  }}
*{{cite journal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |display-authors=3 |author1=Gerhard DS |author2=Wagner L |author3=Feingold EA  |last4=Shenmen |first4=CM |last5=Grouse |first5=LH |last6=Schuler |first6=G |last7=Klein |first7=SL |last8=Old |first8=S |last9=Rasooly |first9=R |pmc=528928 }}
*{{cite journal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=3 |author1=Gregory SG |author2=Barlow KF |author3=McLay KE  |last4=Kaul |first4=R |last5=Swarbreck |first5=D |last6=Dunham |first6=A |last7=Scott |first7=CE |last8=Howe |first8=KL |last9=Woodfine |first9=K }}
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{{Литература крај}}

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{{G protein spregnuti receptori-lat}}

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[[Категорија:Г протеин спрегнути рецептори]]