F-13,714
F-13,714 je agonist 5-HT1A receptora.[3] Studije su pokazale da ligandi 5-HT1A receptora modulišu katalepsiju izazvanu antipsihoticima.
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| Nazivi | |
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| Preferisani IUPAC naziv
(3-hloro-4-fluorofenil)-[4-fluoro-4-[[[5-metil-6-(metilamino)piridin-2-il]metilamino]metil]piperidin-1-il]metanon | |
| Drugi nazivi
CHEMBL45422 • 3-hloro-4-fluorofenil-(4-fluoro-4-(((5-metil-6-metilamino-piridin-2-ilmethyl)-amino)-metil)-piperidin-1-il-metanon) • 3-hloro-4-fluorofenil-(4-fluoro-4-(((5-metil-6-metilaminopiridin-2-ilmetil)amino)metil)piperidin-1-il)metanon • 3-chloro-FPhPNP • F 13714 • F13714
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| Identifikacija | |
3D model (Jmol)
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| Svojstva | |
| C21H25ClF2N4O | |
| Molarna masa | 422,90 g·mol−1 |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
| Reference infokutije | |
Reference
uredi- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Eric P M Prinssen; Francis C Colpaert; Wouter Koek (2002-10-25). „5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsy”. Eur J Pharmacol. 453 (2-3): 217—21. doi:10.1016/s0014-2999(02)02430-5.