Proteinska fosfataza 2

Proteinska fosfataza 2, katalitička jedinica, alfa izoforma
Identifikatori
Simbol	PPP2CA
Entrez	5515
Hugo	9299
OMIM	176915
RefSek	NM_002715
UniProt	P67775
Drugi podaci
EC broj	3.1.3.16
Lokus	Hrom. 5 q23-q31

Proteinska fosfataza 2, katalitička jedinica, beta izoforma
Identifikatori
Simbol	PPP2CB
Entrez	5516
Hugo	9300
OMIM	176916
RefSek	NM_001009552
UniProt	P62714
Drugi podaci
EC broj	3.1.3.16
Lokus	Hrom. 8 p12

Proteinska fosfataza 2 (PP2), takođe poznata kao PP2A, je enzim koji je kod ljudi kodiran PPP2CA genom. PP2A heterotrimerna proteinska fosfataza, je široko zastupljena i konservirana serin/treoninska fosfataza sa širokom supstratnom specifičnošću i različitim ćelijskim funkcijama. Među PP2A metama su proteini onkogene signalne kaskade, poput Raf, MEK, i AKT.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 
• Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y (December 2006). „Structure of the protein phosphatase 2A holoenzyme”. Cell 127 (6): 1239–51. DOI:10.1016/j.cell.2006.11.033. PMID 17174897. 
• Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y (October 2006). „Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins”. Cell 127 (2): 341–53. DOI:10.1016/j.cell.2006.09.025. PMID 17055435. 
• Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK (August 2003). „Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites”. Curr. Biol. 13 (16): 1356–64. DOI:10.1016/S0960-9822(03)00535-9. PMID 12932319. 

Spoljašnje veze

• MeSH PPP2CA+protein,+human