O-2372

O-2372
(IUPAC) ime
	6-((6aR,10aR)-1-hidroksi-6,6,9-trimetil-6a,7,10,10a-tetrahidro-6H-benzo[c]hromen-3-il)-6-metil-1-morfolinoheptan-1-on
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	24848987
Hemijski podaci
Formula	C28H41NO4
Mol. masa	455,629 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C28H41NO4/c1-19-9-10-22-21(16-19)26-23(30)17-20(18-24(26)33-28(22,4)5)27(2,3)11-7-6-8-25(31)29-12-14-32-15-13-29/h9,17-18,21-22,30H,6-8,10-16H2,1-5H3/t21-,22-/m1/s1 ; Key: ASKNFEPPYVJXIA-FGZHOGPDSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

O-2372 je analgetski kanabinoidni derivat koji je kreiralo preduzeće Organix Inc. za primenu u naučnim istraživanjima. On ima visok afinitet za CB₁ i CB₂ receptore, sa K_i vrednostima od 1,3 nM na CB₁ i 0,57 nM na CB₂, ali je u maloj meri rastvoran u vodi u poređenju sa drugim srodnim jedinjenjima, npr. O-2694, čije je metabolit.^[3]

Povezano

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Martin BR, et al. Pharmacological characterization of novel water-soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics. 2006 Sep;318(3):1230-9. PMID 16757541

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Martin BR, et al. Pharmacological characterization of novel water-soluble cannabinoids. Journal of Pharmacology and Experimental Therapeutics. 2006 Sep;318(3):1230-9. PMID 16757541

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