Glutamatna dekarboksilaza
| Glutamatna dekarboksilaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 4.1.1.15 | ||||||||
| CAS broj | 9024-58-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutamatna dekarboksilaza (EC 4.1.1.15, L-glutaminsko kiselinska dekarboksilaza, L-glutaminska dekarboksilaza, cisteinsko kiselinska dekarboksilaza, L-glutamatna alfa-dekarboksilaza, aspartinska alfa-dekarboksilaza, L-aspartat-alfa-dekarboksilaza, gama-glutamatna dekarboksilaza, L-glutamatna 1-karboksi-lijaza) je enzim sa sistematskim imenom L-glutamat 1-karboksi-lijaza (formira 4-aminobutanoat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-glutamat 4-aminobutanoat + CO2
Ovaj enzim je piridoksal-fosfatni protein. Moždani enzim takođe deluje na L-cisteat, 3-sulfino-L-alanin i L-aspartat.
- ↑ Ambe, L. and Sohonie, K. (1963). „Purification and properties of glutamate decarboxylase from the field bean (Dolichos lablab)”. Enzymologia 26: 98-107. PMID 14081858.
- ↑ Nakano, Y. and Kitaoka, S. (1971). „L-Aspartate α-decarboxylase in a cell-free system from Escherichia coli”. J. Biochem. (Tokyo) 70: 327-327. PMID 4937550.
- ↑ Roberts, E. and Frankel, S. (1951). „Further studies of glutamic acid decarboxylase in brain”. J. Biol. Chem. 190: 505-512. PMID 14841200.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.