Koštani morfogenetički protein 2

Koštani morfogenetički protein 2
	; PDB prikaz baziran na 3bmp.
Dostupne strukture
	1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP
Identifikatori
Simboli	BMP2; BDA2; BMP2A
Vanjski ID	OMIM: 112261 MGI: 88177 HomoloGene: 926 GeneCards: BMP2 Gene
Ontologija gena
Molekulska funkcija	• aktivnost retinolne dehidrogenaze; • receptorsko vezivanje; • citokinska aktivnost;
Ćelijska komponenta	• ekstracelularni region; • ekstracelularni prostor; • ćelijska površina;
Biološki proces	• negativna regulacija transkripcije od promotera RNK polimeraze II; • aktivacija MAPK aktivnosti; • razviće skeletalnog sistema;
Pregled RNK izražavanja
	podaci
Ortolozi

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Koštani morfogenetički protein 2 ili BMP-2 pripada TGF-β superfamiliji proteina.^[1]

Funkcija

BMP-2 poput drugih koštano morfogenetičkih proteina,^[2] ima važnu ulogu u razviću kostiju i hrskavice. On učestvuje u hedgehog putu, TGF beta signalnom putu, i interakciji citokina sa citokinskim receptorom. On takođe učestvuje u diferencijaciji srčanih ćelija i epitelijalno mesenhimalnoj tranziciji.

BMP-2 i BMP-7 su osteoinduktivni BMP: demonstrirano je da oni potentno indukuju osteoblastnu diferencijaciju u brojnim tipovima ćelija.^[3]

Interakcije

Koštani morfogenetički protein 2 formira interakcije sa BMPR1A.^[4]^[5]^[6]^[7]

Reference

↑ Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, Ozkaynak E, Oppermann H, Rueger DC (August 1990). „Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily”. J. Biol. Chem. 265 (22): 13198–205. PMID 2376592. Arhivirano iz originala na datum 2005-05-09. Pristupljeno 2014-06-29.
↑ Chen D, Zhao M, Mundy GR (December 2004). „Bone morphogenetic proteins”. Growth Factors 22 (4): 233–41. DOI:10.1080/08977190412331279890. PMID 15621726.
↑ Marie PJ, Debiais F, Haÿ E (2002). „Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling”. Histol. Histopathol. 17 (3): 877–85. PMID 12168799.
↑ Nickel J, Dreyer M K, Kirsch T, Sebald W (2001). „The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists”. The Journal of bone and joint surgery. American volume 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.
↑ Kirsch T, Nickel J, Sebald W (February 2000). „Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2”. FEBS Lett. 468 (2-3): 215–9. DOI:10.1016/S0014-5793(00)01214-X. PMID 10692589.
↑ Kirsch T, Nickel J, Sebald W (July 2000). „BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II”. EMBO J. 19 (13): 3314–24. DOI:10.1093/emboj/19.13.3314. PMC 313944. PMID 10880444.
↑ Gilboa L, Nohe A, Geissendörfer T, Sebald W, Henis Y I, Knaus P (March 2000). „Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors”. Mol. Biol. Cell 11 (3): 1023–35. DOI:10.1091/mbc.11.3.1023. PMC 14828. PMID 10712517.

Literatura

Nickel J, Dreyer MK, Kirsch T, Sebald W (2001). „The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists.”. The Journal of bone and joint surgery. American volume 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.
Kawamura C, Kizaki M, Ikeda Y (2003). „Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.”. Leuk. Lymphoma 43 (3): 635–9. DOI:10.1080/10428190290012182. PMID 12002771.
Marie PJ, Debiais F, Haÿ E (2003). „Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling.”. Histol. Histopathol. 17 (3): 877–85. PMID 12168799.

Vanjske veze

[pmid2376592-1] Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, Ozkaynak E, Oppermann H, Rueger DC (August 1990). „Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily”. J. Biol. Chem. 265 (22): 13198–205. PMID 2376592. Arhivirano iz originala na datum 2005-05-09. Pristupljeno 2014-06-29.

[pmid15621726-2] Chen D, Zhao M, Mundy GR (December 2004). „Bone morphogenetic proteins”. Growth Factors 22 (4): 233–41. DOI:10.1080/08977190412331279890. PMID 15621726.

[pmid12168799-3] Marie PJ, Debiais F, Haÿ E (2002). „Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling”. Histol. Histopathol. 17 (3): 877–85. PMID 12168799.

[pmid11263668-4] Nickel J, Dreyer M K, Kirsch T, Sebald W (2001). „The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists”. The Journal of bone and joint surgery. American volume 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.

[pmid10692589-5] Kirsch T, Nickel J, Sebald W (February 2000). „Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2”. FEBS Lett. 468 (2-3): 215–9. DOI:10.1016/S0014-5793(00)01214-X. PMID 10692589.

[pmid10880444-6] Kirsch T, Nickel J, Sebald W (July 2000). „BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II”. EMBO J. 19 (13): 3314–24. DOI:10.1093/emboj/19.13.3314. PMC 313944. PMID 10880444.

[pmid10712517-7] Gilboa L, Nohe A, Geissendörfer T, Sebald W, Henis Y I, Knaus P (March 2000). „Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors”. Mol. Biol. Cell 11 (3): 1023–35. DOI:10.1091/mbc.11.3.1023. PMC 14828. PMID 10712517.

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