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Ajmalin

Izvor: Wikipedija
Ajmalin
(IUPAC) ime
(17R,21β)-ajmalan- 17,21-diol
ili
(1R,9R,10S,13R,14R,16S,18S)- 13-etil- 8-metil- 8,15-diazaheksaciklo [14.2.1.01,9.02,7.010,15.012,17] nonadeka- 2(7),3,5-trien- 14,18-diol
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 4360-12-7
ATC kod C01BA05
PubChem[1][2] 20367
DrugBank DB01426
ChemSpider[3] 10469368
UNII 1PON08459R DaY
KEGG[4] D00199 DaY
ChEMBL[5] CHEMBL1230919 DaY
Hemijski podaci
Formula C20H26N2O2 
Mol. masa 326,433 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Ajmalin je alkaloid iz klase Ia antiaritmičkih agenasa. On se često koristi za tretman ST elevacija kod pacijenata sa Brugada sindromom.

Ovo jedinjenje je originalno izolovano 1931.[6] iz korena biljke Rauwolfia serpentina. Ime je dobilo po Hakim Ajmal Kanu, čuvenom lekaru iz oblasti Unani medicine u Južnoj Aziji.[7]

Reference

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  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Salimuzzaman Siddiqui, Siddiqui, R. H. (1931). J. Indian Chem. Soc. 8: 667–80.
  7. Ahmed Nasim Sandilvi (2003), Salimuzzaman Siddiqui: pioneer of scientific research in Pakistan. Daily Dawn. 12 April 2003. Retrieved on 19 July 2007.

Povezano

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