F2RL3

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Proteazom-aktivirani receptor 4
Identifikatori
Simboli	F2RL3; PAR4
Vanjski ID	OMIM: 602779 MGI: 1298207 HomoloGene: 36148 IUPHAR: PAR4 GeneCards: F2RL3 Gene
Ontologija gena Molekularna funkcija • rodopsinu-slična receptorska aktivnost • receptorska aktivnost • aktivnost trombinskog receptora Celularna komponenta • membrana plazme • integralno sa membranom plazme Biološki proces • prenos signala • G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom • koagulacija krvi • respons na ranjavanje
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	9002	14065
Ensembl	ENSG00000127533	ENSMUSG00000050147
UniProt	Q96RI0	Q0VDX1
RefSeq (mRNA)	NM_003950	NM_007975
RefSeq (protein)	NP_003941	NP_032001
Lokacija (UCSC)	Chr 19: 16.86 - 16.87 Mb	Chr 8: 75.66 - 75.66 Mb
PubMed pretraga	[1]	[2]

Proteazom-aktivirani receptor 4 (PAR4), ili Receptoru koagulacionog faktora II (trombina) sličan 3, je protein kodiran F2RL3 genom kod ljudi.

F2RL3 je član velike familije G-protein spregnutih receptora koji interaguju sa guanozin-nukleotid-vezujućim proteinima. PAR4 je takođe član familije proteazom aktiviranih receptora. On je aktiviran trombinom i tripsinom. Do aktivacije dolazi proteolitičkim odsecanjem njegovog ekstracelularnog amino terminusa. Novo-formirani amino terminus dejstvuje kao vezani ligand i aktivira receptor.

Vidi još

• Proteazom-aktivirani receptor

Literatura

• Leger AJ, Covic L, Kuliopulos A (2006). „Protease-activated receptors in cardiovascular diseases.”. Circulation 114 (10): 1070–7. DOI:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995. 
• Xu WF, Andersen H, Whitmore TE, et al. (1998). „Cloning and characterization of human protease-activated receptor 4.”. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. DOI:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465. 
• Kahn ML, Zheng YW, Huang W, et al. (1998). „A dual thrombin receptor system for platelet activation.”. Nature 394 (6694): 690–4. DOI:10.1038/29325. PMID 9716134. 
• Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). „Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.”. J. Biol. Chem. 273 (36): 23290–6. DOI:10.1074/jbc.273.36.23290. PMID 9722561. 
• Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). „Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.”. J. Clin. Invest. 103 (6): 879–87. DOI:10.1172/JCI6042. PMC 408153. PMID 10079109. 
• Andersen H, Greenberg DL, Fujikawa K, et al. (1999). „Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity.”. Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189–93. DOI:10.1073/pnas.96.20.11189. PMC 18009. PMID 10500152. 
• Sambrano GR, Huang W, Faruqi T, et al. (2000). „Cathepsin G activates protease-activated receptor-4 in human platelets.”. J. Biol. Chem. 275 (10): 6819–23. DOI:10.1074/jbc.275.10.6819. PMID 10702240. 
• Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). „PAR3 is a cofactor for PAR4 activation by thrombin.”. Nature 404 (6778): 609–13. DOI:10.1038/35007085. PMID 10766244. 
• Miike S, McWilliam AS, Kita H (2002). „Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.”. J. Immunol. 167 (11): 6615–22. PMID 11714832. 
• Asokananthan N, Graham PT, Fink J, et al. (2002). „Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.”. J. Immunol. 168 (7): 3577–85. PMID 11907122. 
• Henriksen RA, Hanks VK (2002). „PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets.”. Arterioscler. Thromb. Vasc. Biol. 22 (5): 861–6. DOI:10.1161/01.ATV.0000014742.56572.25. PMID 12006403. 
• Covic L, Singh C, Smith H, Kuliopulos A (2003). „Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.”. Thromb. Haemost. 87 (4): 722–7. PMID 12008957. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Owen WG (2003). „PAR-3 is a low-affinity substrate, high affinity effector of thrombin.”. Biochem. Biophys. Res. Commun. 305 (1): 166–8. DOI:10.1016/S0006-291X(03)00732-0. PMID 12732212. 
• Adam F, Verbeuren TJ, Fauchère JL, et al. (2003). „Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.”. J. Thromb. Haemost. 1 (4): 798–804. DOI:10.1046/j.1538-7836.2003.00138.x. PMID 12871418. 
• Wu CC, Hwang TL, Liao CH, et al. (2004). „The role of PAR4 in thrombin-induced thromboxane production in human platelets.”. Thromb. Haemost. 90 (2): 299–308. DOI:10.1267/THRO03020299. PMID 12888878. 
• Kawai T, Akira S, Reed JC (2003). „ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.”. Mol. Cell. Biol. 23 (17): 6174–86. DOI:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339. 
• Jacques SL, Kuliopulos A (2004). „Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.”. Biochem. J. 376 (Pt 3): 733–40. DOI:10.1042/BJ20030954. PMC 1223816. PMID 13678420. 
• Han Y, Nurden A, Combrié R, Pasquet JM (2004). „Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.”. J. Thromb. Haemost. 1 (10): 2206–15. DOI:10.1046/j.1538-7836.2003.00436.x. PMID 14521606. 
• „Protease-Activated Receptors: PAR4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.