Alfa-2B adrenergički receptor

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Adrenergički alfa-2B receptor
Identifikatori
Simboli	ADRA2B; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR
Vanjski ID	OMIM: 104260 MGI: 87935 HomoloGene: 553 IUPHAR: α2B-adrenoceptor GeneCards: ADRA2B Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • adrenoceptorska aktivnost • aktivnost alfa2-adrenergičkog receptora Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • prenos signala • signalni put G-protein spregnutog receptora • interćelijska signalizacija
Ortolozi
Vrsta	Čovek	Miš
Entrez	151	11552
Ensembl	n/a	ENSMUSG00000058620
UniProt	P18089	P30545
RefSeq (mRNA)	NM_000682	NM_009633
RefSeq (protein)	NP_000673	NP_033763
Lokacija (UCSC)	n/a	Chr 2: 127.05 - 127.06 Mb
PubMed pretraga	[1]	[2]

Alfa-2B adrenergički receptor (α_2B adrenoceptor) je G-protein spregnuti receptor. On je tip adrenergičke receptorske familije. Humani gen koji kodira ovaj receptor ima simbol ADRA2B. ADRA2B ortolozi su identifikovani kod nekoliko sisara.

Receptor

Postoje tri visoko homologna tipa alfa-2-adrenergičkog receptora: alfa_2A, alfa_2B, i alfa_2C. Ti receptori učestvuju u regulaciji otpuštanja neurotransmitera iz simpatičkih nerva i iz adrenergičkih neurona centralnog nervnog sistema.

Gen

Ovaj gen kodira alfa_2B tip receptora. On se vezuje za eIF-2B, faktor razmene guanin nukleotida koji učestvuje u regulaciji translacije. Za polimorfnu varijantu alfa_2B tip, kojoj nedostaju 3 glutaminske kiseline iz elementa ponavljanja glutaminskih kiselina, je ustanoljeno da ima umanjenu GPCR kinazama-posredovanu fosforilaciju i desenzitizaciju. Ova polimorfna forma je isto tako povezana sa umanjenom bazalnim metabolizmom kod gojaznih osoba i moguće je da doprinosi patogenezi gojaznosti. Ovaj gen ne sadrži introne.

Selektivni ligandi

Antagonisti

• Imiloksan
• Johimbin

Povezano

• Adrenergički receptor

Literatura

• Lomasney JW, Lorenz W, Allen LF, et al. (1990). „Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.”. Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5094–8. DOI:10.1073/pnas.87.13.5094. PMC 54268. PMID 2164221. 
• McClue SJ, Milligan G (1990). „The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2.”. FEBS Lett. 269 (2): 430–4. DOI:10.1016/0014-5793(90)81209-7. PMID 2169434. 
• Weinshank RL, Zgombick JM, Macchi M, et al. (1990). „Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.”. Mol. Pharmacol. 38 (5): 681–8. PMID 2172775. 
• Chang AC, Ho TF, Chang NC (1990). „In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.”. Biochem. Biophys. Res. Commun. 172 (2): 817–23. DOI:10.1016/0006-291X(90)90748-C. PMID 2173582. 
• Regan JW, Kobilka TS, Yang-Feng TL, et al. (1988). „Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.”. Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6301–5. DOI:10.1073/pnas.85.17.6301. PMC 281957. PMID 2842764. 
• Petrash AC, Bylund DB (1986). „Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain.”. Life Sci. 38 (23): 2129–37. DOI:10.1016/0024-3205(86)90212-2. PMID 3012234. 
• Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). „A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.”. J. Biol. Chem. 272 (31): 19099–102. DOI:10.1074/jbc.272.31.19099. PMID 9235896. 
• Okusa MD, Huang L, Momose-Hotokezaka A, et al. (1998). „Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors.”. Am. J. Physiol. 273 (6 Pt 2): F883–91. PMID 9435676. 
• Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). „The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.”. J. Biol. Chem. 274 (19): 13462–9. DOI:10.1074/jbc.274.19.13462. PMID 10224112. 
• Heinonen P, Koulu M, Pesonen U, et al. (1999). „Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.”. J. Clin. Endocrinol. Metab. 84 (7): 2429–33. DOI:10.1210/jc.84.7.2429. PMID 10404816. 
• Hein L, Altman JD, Kobilka BK (2000). „Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.”. Nature 402 (6758): 181–4. DOI:10.1038/46040. PMID 10647009. 
• Small KM, Brown KM, Forbes SL, Liggett SB (2001). „Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.”. J. Biol. Chem. 276 (7): 4917–22. DOI:10.1074/jbc.M008118200. PMID 11056163. 
• Snapir A, Mikkelsson J, Perola M, et al. (2003). „Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.”. J. Am. Coll. Cardiol. 41 (2): 190–4. DOI:10.1016/S0735-1097(02)02702-X. PMID 12535806. 
• Sykiotis GP, Polyzogopoulou E, Georgopoulos NA, et al. (2004). „The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.”. Clin. Auton. Res. 13 (3): 203–7. DOI:10.1007/s10286-003-0087-5. PMID 12822042. 
• Chotani MA, Mitra S, Su BY, et al. (2004). „Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.”. Am. J. Physiol. Heart Circ. Physiol. 286 (1): H59–67. DOI:10.1152/ajpheart.00268.2003. PMID 12946937. 
• Von Wowern F, Bengtsson K, Lindblad U, et al. (2004). „Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.”. Hypertension 43 (3): 592–7. DOI:10.1161/01.HYP.0000116224.51189.80. PMID 14744925. 
• Cayla C, Heinonen P, Viikari L, et al. (2004). „Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.”. Biochem. Pharmacol. 67 (3): 469–78. DOI:10.1016/j.bcp.2003.09.029. PMID 15037199. 
• Phares DA, Halverstadt AA, Shuldiner AR, et al. (2004). „Association between body fat response to exercise training and multilocus ADR genotypes.”. Obes. Res. 12 (5): 807–15. DOI:10.1038/oby.2004.97. PMID 15166301. 
• Siitonen N, Lindström J, Eriksson J, et al. (2005). „Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study.”. Diabetologia 47 (8): 1416–24. DOI:10.1007/s00125-004-1462-z. PMID 15309292. 
• Belfer I, Buzas B, Hipp H, et al. (2005). „Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene.”. J. Hum. Genet. 50 (1): 12–20. DOI:10.1007/s10038-004-0211-y. PMID 15592690. 

Spoljašnje veze

• „α_2B-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-05.