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* [[Proteazom-aktivirani receptor]] |
* [[Proteazom-aktivirani receptor]] |
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*{{cite journal | author=Kahn ML, Zheng YW, Huang W, ''et al.'' |title=A dual thrombin receptor system for platelet activation. |journal=Nature |volume=394 |issue= 6694 |pages= 690–4 |year= 1998 |pmid= 9716134 |doi= 10.1038/29325 }} |
*{{cite journal | author=Kahn ML, Zheng YW, Huang W, ''et al.'' |title=A dual thrombin receptor system for platelet activation. |journal=Nature |volume=394 |issue= 6694 |pages= 690–4 |year= 1998 |pmid= 9716134 |doi= 10.1038/29325 }} |
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*{{cite journal | author=Kahn ML, Hammes SR, Botka C, Coughlin SR |title=Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23290–6 |year= 1998 |pmid= 9722561 |doi=10.1074/jbc.273.36.23290 }} |
*{{cite journal | author=Kahn ML, Hammes SR, Botka C, Coughlin SR |title=Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23290–6 |year= 1998 |pmid= 9722561 |doi=10.1074/jbc.273.36.23290 }} |
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*{{cite journal |
*{{cite journal |author= Kahn ML, Nakanishi-Matsui M, Shapiro MJ, ''et al.'' |title= Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. |url= https://archive.org/details/sim_journal-of-clinical-investigation_1999-03_103_6/page/879 |journal= J. Clin. Invest. |volume= 103 |issue= 6 |pages= 879–87 |year= 1999 |pmid= 10079109 |doi= 10.1172/JCI6042 |pmc= 408153 }} |
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*{{cite journal | author=Andersen H, Greenberg DL, Fujikawa K, ''et al.'' |title=Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11189–93 |year= 1999 |pmid= 10500152 |doi=10.1073/pnas.96.20.11189 | pmc=18009 }} |
*{{cite journal | author=Andersen H, Greenberg DL, Fujikawa K, ''et al.'' |title=Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11189–93 |year= 1999 |pmid= 10500152 |doi=10.1073/pnas.96.20.11189 | pmc=18009 }} |
||
*{{cite journal | author=Sambrano GR, Huang W, Faruqi T, ''et al.'' |title=Cathepsin G activates protease-activated receptor-4 in human platelets. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 6819–23 |year= 2000 |pmid= 10702240 |doi=10.1074/jbc.275.10.6819 }} |
*{{cite journal | author=Sambrano GR, Huang W, Faruqi T, ''et al.'' |title=Cathepsin G activates protease-activated receptor-4 in human platelets. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 6819–23 |year= 2000 |pmid= 10702240 |doi=10.1074/jbc.275.10.6819 }} |
||
| Red 28: | Red 28: | ||
*{{cite journal | author=Miike S, McWilliam AS, Kita H |title=Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6615–22 |year= 2002 |pmid= 11714832 |doi= }} |
*{{cite journal | author=Miike S, McWilliam AS, Kita H |title=Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6615–22 |year= 2002 |pmid= 11714832 |doi= }} |
||
*{{cite journal | author=Asokananthan N, Graham PT, Fink J, ''et al.'' |title=Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3577–85 |year= 2002 |pmid= 11907122 |doi= }} |
*{{cite journal | author=Asokananthan N, Graham PT, Fink J, ''et al.'' |title=Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3577–85 |year= 2002 |pmid= 11907122 |doi= }} |
||
*{{cite journal |
*{{cite journal |author= Henriksen RA, Hanks VK |title= PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets. |url= https://archive.org/details/sim_arteriosclerosis-thrombosis-and-vascular-biology_2002-05_22_5/page/861 |journal= Arterioscler. Thromb. Vasc. Biol. |volume= 22 |issue= 5 |pages= 861–6 |year= 2002 |pmid= 12006403 |doi= 10.1161/01.ATV.0000014742.56572.25 }} |
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*{{cite journal | author=Covic L, Singh C, Smith H, Kuliopulos A |title=Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome. |journal=Thromb. Haemost. |volume=87 |issue= 4 |pages= 722–7 |year= 2003 |pmid= 12008957 |doi= }} |
*{{cite journal | author=Covic L, Singh C, Smith H, Kuliopulos A |title=Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome. |journal=Thromb. Haemost. |volume=87 |issue= 4 |pages= 722–7 |year= 2003 |pmid= 12008957 |doi= }} |
||
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} |
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} |
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| Red 34: | Red 34: | ||
*{{cite journal | author=Adam F, Verbeuren TJ, Fauchère JL, ''et al.'' |title=Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP. |journal=J. Thromb. Haemost. |volume=1 |issue= 4 |pages= 798–804 |year= 2003 |pmid= 12871418 |doi=10.1046/j.1538-7836.2003.00138.x }} |
*{{cite journal | author=Adam F, Verbeuren TJ, Fauchère JL, ''et al.'' |title=Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP. |journal=J. Thromb. Haemost. |volume=1 |issue= 4 |pages= 798–804 |year= 2003 |pmid= 12871418 |doi=10.1046/j.1538-7836.2003.00138.x }} |
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*{{cite journal | author=Wu CC, Hwang TL, Liao CH, ''et al.'' |title=The role of PAR4 in thrombin-induced thromboxane production in human platelets. |journal=Thromb. Haemost. |volume=90 |issue= 2 |pages= 299–308 |year= 2004 |pmid= 12888878 |doi= 10.1267/THRO03020299 }} |
*{{cite journal | author=Wu CC, Hwang TL, Liao CH, ''et al.'' |title=The role of PAR4 in thrombin-induced thromboxane production in human platelets. |journal=Thromb. Haemost. |volume=90 |issue= 2 |pages= 299–308 |year= 2004 |pmid= 12888878 |doi= 10.1267/THRO03020299 }} |
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*{{cite journal |
*{{cite journal |author= Kawai T, Akira S, Reed JC |title= ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. |url= https://archive.org/details/sim_molecular-and-cellular-biology_2003-09_23_17/page/6174 |journal= Mol. Cell. Biol. |volume= 23 |issue= 17 |pages= 6174–86 |year= 2003 |pmid= 12917339 |doi= 10.1128/MCB.23.17.6174-6186.2003 |pmc= 180930 }} |
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*{{cite journal | author=Jacques SL, Kuliopulos A |title=Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. |journal=Biochem. J. |volume=376 |issue= Pt 3 |pages= 733–40 |year= 2004 |pmid= 13678420 |doi= 10.1042/BJ20030954 | pmc=1223816 }} |
*{{cite journal | author=Jacques SL, Kuliopulos A |title=Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. |journal=Biochem. J. |volume=376 |issue= Pt 3 |pages= 733–40 |year= 2004 |pmid= 13678420 |doi= 10.1042/BJ20030954 | pmc=1223816 }} |
||
*{{cite journal | author=Han Y, Nurden A, Combrié R, Pasquet JM |title=Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium. |journal=J. Thromb. Haemost. |volume=1 |issue= 10 |pages= 2206–15 |year= 2004 |pmid= 14521606 |doi=10.1046/j.1538-7836.2003.00436.x }} |
*{{cite journal | author=Han Y, Nurden A, Combrié R, Pasquet JM |title=Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium. |journal=J. Thromb. Haemost. |volume=1 |issue= 10 |pages= 2206–15 |year= 2004 |pmid= 14521606 |doi=10.1046/j.1538-7836.2003.00436.x }} |
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*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3036 | title = Protease-Activated Receptors: PAR4 | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }} |
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3036 | title = Protease-Activated Receptors: PAR4 | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = https://web.archive.org/web/20120402213020/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3036 | archivedate = 2012-04-02 | quote = | dead-url = yes }} |
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Aktualna verzija od 18. augusta 2024. u 01:18
| edit |
| Proteazom-aktivirani receptor 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | F2RL3; PAR4 | ||||||||||
| Vanjski ID | OMIM: 602779 MGI: 1298207 HomoloGene: 36148 IUPHAR: PAR4 GeneCards: F2RL3 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 9002 | 14065 | |||||||||
| Ensembl | ENSG00000127533 | ENSMUSG00000050147 | |||||||||
| UniProt | Q96RI0 | Q0VDX1 | |||||||||
| RefSeq (mRNA) | NM_003950 | NM_007975 | |||||||||
| RefSeq (protein) | NP_003941 | NP_032001 | |||||||||
| Lokacija (UCSC) | Chr 19: 16.86 - 16.87 Mb | Chr 8: 75.66 - 75.66 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Proteazom-aktivirani receptor 4 (PAR4), ili Receptoru koagulacionog faktora II (trombina) sličan 3, je protein kodiran F2RL3 genom kod ljudi.[1]
F2RL3 je član velike familije G-protein spregnutih receptora koji interaguju sa guanozin-nukleotid-vezujućim proteinima. PAR4 je takođe član familije proteazom aktiviranih receptora. On je aktiviran trombinom i tripsinom. Do aktivacije dolazi proteolitičkim odsecanjem njegovog ekstracelularnog amino terminusa. Novo-formirani amino terminus dejstvuje kao vezani ligand i aktivira receptor.[1]
- Leger AJ, Covic L, Kuliopulos A (2006). „Protease-activated receptors in cardiovascular diseases.”. Circulation 114 (10): 1070–7. DOI:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995.
- Xu WF, Andersen H, Whitmore TE, et al. (1998). „Cloning and characterization of human protease-activated receptor 4.”. Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. DOI:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465.
- Kahn ML, Zheng YW, Huang W, et al. (1998). „A dual thrombin receptor system for platelet activation.”. Nature 394 (6694): 690–4. DOI:10.1038/29325. PMID 9716134.
- Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). „Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.”. J. Biol. Chem. 273 (36): 23290–6. DOI:10.1074/jbc.273.36.23290. PMID 9722561.
- Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). „Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.”. J. Clin. Invest. 103 (6): 879–87. DOI:10.1172/JCI6042. PMC 408153. PMID 10079109.
- Andersen H, Greenberg DL, Fujikawa K, et al. (1999). „Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity.”. Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189–93. DOI:10.1073/pnas.96.20.11189. PMC 18009. PMID 10500152.
- Sambrano GR, Huang W, Faruqi T, et al. (2000). „Cathepsin G activates protease-activated receptor-4 in human platelets.”. J. Biol. Chem. 275 (10): 6819–23. DOI:10.1074/jbc.275.10.6819. PMID 10702240.
- Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). „PAR3 is a cofactor for PAR4 activation by thrombin.”. Nature 404 (6778): 609–13. DOI:10.1038/35007085. PMID 10766244.
- Miike S, McWilliam AS, Kita H (2002). „Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.”. J. Immunol. 167 (11): 6615–22. PMID 11714832.
- Asokananthan N, Graham PT, Fink J, et al. (2002). „Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.”. J. Immunol. 168 (7): 3577–85. PMID 11907122.
- Henriksen RA, Hanks VK (2002). „PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets.”. Arterioscler. Thromb. Vasc. Biol. 22 (5): 861–6. DOI:10.1161/01.ATV.0000014742.56572.25. PMID 12006403.
- Covic L, Singh C, Smith H, Kuliopulos A (2003). „Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.”. Thromb. Haemost. 87 (4): 722–7. PMID 12008957.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Owen WG (2003). „PAR-3 is a low-affinity substrate, high affinity effector of thrombin.”. Biochem. Biophys. Res. Commun. 305 (1): 166–8. DOI:10.1016/S0006-291X(03)00732-0. PMID 12732212.
- Adam F, Verbeuren TJ, Fauchère JL, et al. (2003). „Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.”. J. Thromb. Haemost. 1 (4): 798–804. DOI:10.1046/j.1538-7836.2003.00138.x. PMID 12871418.
- Wu CC, Hwang TL, Liao CH, et al. (2004). „The role of PAR4 in thrombin-induced thromboxane production in human platelets.”. Thromb. Haemost. 90 (2): 299–308. DOI:10.1267/THRO03020299. PMID 12888878.
- Kawai T, Akira S, Reed JC (2003). „ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.”. Mol. Cell. Biol. 23 (17): 6174–86. DOI:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
- Jacques SL, Kuliopulos A (2004). „Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.”. Biochem. J. 376 (Pt 3): 733–40. DOI:10.1042/BJ20030954. PMC 1223816. PMID 13678420.
- Han Y, Nurden A, Combrié R, Pasquet JM (2004). „Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.”. J. Thromb. Haemost. 1 (10): 2206–15. DOI:10.1046/j.1538-7836.2003.00436.x. PMID 14521606.
- „Protease-Activated Receptors: PAR4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-04-02.