CD83

CD83
Identificadores
Nomes alternativos	CD83, Grupo de Diferenciação 83
IDs externos	OMIM: 604534 HomoloGene: 3121 GeneCards: CD83
Ontologia genética
Função molecular	• GO:0001948, GO:0016582 ligação a proteínas plasmáticas;
Componente celular	• integral component of membrane; • membrana plasmática; • integral component of plasma membrane; • external side of plasma membrane; • membrane;
Processo biológico	• GO:0032657 regulation of cytokine production; • defense response; • positive regulation of CD4-positive, alpha-beta T cell differentiation; • humoral immune response; • GO:1904578 response to organic cyclic compound; • positive regulation of interleukin-2 production; • negative regulation of interleukin-4 production; • GO:0072468 transdução de sinal; • positive regulation of interleukin-10 production;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	9308
	n/a
	ENSG00000112149
	n/a
	Q01151
	n/a
	NM_004233; NM_001040280; NM_001251901
	n/a
	NP_001035370; NP_001238830; NP_004224
	n/a
	Wikidata
Ver/Editar Humano

CD83 (Grupo de Diferenciação 83) é uma proteína humana codificada pelo gene CD83.^[2]

Referências

Leitura adicional

Lechmann M, Berchtold S, Hauber J, Steinkasserer A (2002). «CD83 on dendritic cells: more than just a marker for maturation.». Trends Immunol. 23 (6): 273–5. PMID 12072358. doi:10.1016/S1471-4906(02)02214-7
Zhou LJ, Schwarting R, Smith HM, Tedder TF (1992). «A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily.». J. Immunol. 149 (2): 735–42. PMID 1378080
Zhou LJ, Tedder TF (1995). «Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.». J. Immunol. 154 (8): 3821–35. PMID 7706722
Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.». Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
Kozlow EJ, Wilson GL, Fox CH, Kehrl JH (1993). «Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes». Blood. 81 (2): 454–61. PMID 8422464
de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P (1997). «CD84 leukocyte antigen is a new member of the Ig superfamily». Blood. 90 (6): 2398–405. PMID 9310491
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library». Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
Olavesen MG, Bentley E, Mason RV, Stephens RJ, Ragoussis J (1998). «Fine mapping of 39 ESTs on human chromosome 6p23-p25». Genomics. 46 (2): 303–6. PMID 9417921. doi:10.1006/geno.1997.5032
Twist CJ, Beier DR, Disteche CM, Edelhoff S, Tedder TF (1998). «The mouse Cd83 gene: structure, domain organization, and chromosome localization». Immunogenetics. 48 (6): 383–93. PMID 9799334. doi:10.1007/s002510050449
Berchtold S, Mühl-Zürbes P, Heufler C, Winklehner P, Schuler G, Steinkasserer A (1999). «Cloning, recombinant expression and biochemical characterization of the murine CD83 molecule which is specifically upregulated during dendritic cell maturation». FEBS Lett. 461 (3): 211–6. PMID 10567699. doi:10.1016/S0014-5793(99)01465-9
Scholler N, Hayden-Ledbetter M, Hellström KE, Hellström I, Ledbetter JA (2001). «CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells». J. Immunol. 166 (6): 3865–72. PMID 11238630. doi:10.4049/jimmunol.166.6.3865
Fanales-Belasio E, Moretti S, Nappi F, Barillari G, Micheletti F, Cafaro A, Ensoli B (2002). «Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses». J. Immunol. 168 (1): 197–206. PMID 11751963. doi:10.4049/jimmunol.168.1.197
Berchtold S, Mühl-Zürbes P, Maczek E, Golka A, Schuler G, Steinkasserer A (2003). «Cloning and characterization of the promoter region of the human CD83 gene». Immunobiology. 205 (3): 231–46. PMID 12182451. doi:10.1078/0171-2985-00128
te Velde AA, van Kooyk Y, Braat H, Hommes DW, Dellemijn TA, Slors JF, van Deventer SJ, Vyth-Dreese FA (2003). «Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease». Eur. J. Immunol. 33 (1): 143–51. PMID 12594843. doi:10.1002/immu.200390017
Dudziak D, Kieser A, Dirmeier U, Nimmerjahn F, Berchtold S, Steinkasserer A, Marschall G, Hammerschmidt W, Laux G, Bornkamm GW (2003). «Latent Membrane Protein 1 of Epstein-Barr Virus Induces CD83 by the NF-κB Signaling Pathway». J. Virol. 77 (15): 8290–8. PMC 165234. PMID 12857898. doi:10.1128/JVI.77.15.8290-8298.2003
Hock BD, Haring LF, Steinkasserer A, Taylor KG, Patton WN, McKenzie JL (2004). «The soluble form of CD83 is present at elevated levels in a number of hematological malignancies». Leuk. Res. 28 (3): 237–41. PMID 14687618. doi:10.1016/S0145-2126(03)00255-8
Sénéchal B, Boruchov AM, Reagan JL, Hart DN, Young JW (2004). «Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83». Blood. 103 (11): 4207–15. PMID 14962896. doi:10.1182/blood-2003-12-4350
Cao W, Lee SH, Lu J (2005). «CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells». Biochem. J. 385 (Pt 1): 85–93. PMC 1134676. PMID 15320871. doi:10.1042/BJ20040741

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[1] «Human PubMed Reference:»

[2] «Entrez Gene: CD83 CD83 molecule»

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