Wikidata

(Q994646)

English

Fas associated via death domain

mammalian protein found in Homo sapiens

  • growth-inhibiting gene 3 protein
  • FADD
  • Mediator of receptor induced toxicity
  • FAS-associated death domain protein
  • Fas (TNFRSF6)-associated via death domain
  • Fas-associating death domain-containing protein
  • Protein FADD
  • Fas-associating protein with death domain
  • mediator of receptor-induced toxicity
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
45 references
retrieved
9 May 2019
stated in
Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation
GOA
curator
UniProt
UniProt protein ID
Q13158
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
GOA
curator
UniProt
UniProt protein ID
Q13158
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation
GOA
curator
UniProt
UniProt protein ID
Q13158
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
Q13158
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Casper is a FADD- and caspase-related inducer of apoptosis
GOA
curator
UniProt
UniProt protein ID
Q13158
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
The apoptotic signaling pathway activated by Toll-like receptor-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
A type III effector antagonizes death receptor signalling during bacterial gut infection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
The Fas-FADD death domain complex structure unravels signalling by receptor clustering
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Apo2L/TRAIL and the death receptor 5 agonist antibody AMG 655 cooperate to promote receptor clustering and antitumor activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Yes and PI3K bind CD95 to signal invasion of glioblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
The role of receptor internalization in CD95 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
TNF-alpha induces two distinct caspase-8 activation pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
retrieved
9 May 2019
stated in
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13158
determination method or standard
IPI
cell component
biological process
Gene Atlas image
PBB GE FADD 202535 at fs.png
732 × 530; 11 KB
0 references

Identifiers

UniProt protein ID
Q13158
0 references
 
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