(Q54468428)

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19 February 2020

title

Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression (English)

1 reference

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19 February 2020

1 reference

3

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19 February 2020

author name string

Wonseok Yang

1

1 reference

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19 February 2020

Ji-hyun Ju

2

1 reference

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19 February 2020

KeeSoo Nam

4

1 reference

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19 February 2020

Sunhwa Oh

5

1 reference

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19 February 2020

Incheol Shin

6

1 reference

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19 February 2020

language of work or name

English

0 references

publication date

30 November 2012

1 reference

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Experimental Cell Research

19 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23200933%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

319

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19 February 2020

issue

3

1 reference

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19 February 2020

page(s)

122-133

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Autophagy in health and disease: a double-edged sword

19 February 2020

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

7 January 2021

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Excess peroxisomes are degraded by autophagic machinery in mammals

7 January 2021

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7 January 2021

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Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

7 January 2021

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Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

7 January 2021

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Dynein mutations impair autophagic clearance of aggregate-prone proteins

7 January 2021

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

7 January 2021

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Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment

7 January 2021

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Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma

7 January 2021

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

7 January 2021

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Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21

7 January 2021

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The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function

7 January 2021

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7 January 2021

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7 January 2021

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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

7 January 2021

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Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

7 January 2021

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Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus

7 January 2021

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UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation

7 January 2021

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A critical role for UVRAG in apoptosis

7 January 2021

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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

7 January 2021

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

7 January 2021

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Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells

7 January 2021

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

7 January 2021

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Akt isoform-specific inhibition of MDA-MB-231 cell proliferation

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Targeting protective autophagy exacerbates UV-triggered apoptotic cell death

7 January 2021

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Sensitization to radiation-induced DNA damage accelerates loss of bcl-2 and increases apoptosis and autophagy

7 January 2021

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7 January 2021

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7 January 2021

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Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

7 January 2021

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HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

7 January 2021

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7 January 2021

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Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

7 January 2021

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Complementation of the UV-sensitive phenotype of a xeroderma pigmentosum human cell line by transfection with a cDNA clone library

7 January 2021

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Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells

7 January 2021

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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

7 January 2021

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Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1

7 January 2021

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A dual role for UVRAG in maintaining chromosomal stability independent of autophagy

7 January 2021

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The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

7 January 2021

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Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation

7 January 2021

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10.1016/J.YEXCR.2012.11.014

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23200933%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference