Wikidata

(Q5198256)

English

Cyclin dependent kinase 9

mammalian protein found in Homo sapiens

  • cell division cycle 2-like protein kinase 4
  • CDC2-related kinase
  • C-2K
  • serine/threonine protein kinase PITALRE
  • cell division protein kinase 9
  • CDK9
  • cyclin-dependent kinase 9
  • tat-associated kinase complex catalytic subunit
  • Serine/threonine-protein kinase PITALRE
In more languages
default values for all languages
No label defined

No description defined

Statements

molecular function
protein binding
determination method
IPI
33 references
retrieved
8 April 2019
stated in
Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb
GOA
curator
UniProt
UniProt protein ID
P50750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Pkn is a novel partner of cyclin T2a in muscle differentiation
GOA
curator
UniProt
UniProt protein ID
P50750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release
GOA
curator
UniProt
UniProt protein ID
P50750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Identification of multiple cyclin subunits of human P-TEFb
GOA
curator
UniProt
UniProt protein ID
P50750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner
GOA
curator
UniProt
UniProt protein ID
P50750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II
GOA
curator
UniProt
UniProt protein ID
P50750
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
RNA helicase DDX21 coordinates transcription and ribosomal RNA processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of HIV-1 Tat complexed with human P-TEFb
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Cyclin‐dependent kinase 9–cyclin K functions in the replication stress response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Global landscape of HIV-human protein complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Human mediator subunit MED26 functions as a docking site for transcription elongation factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
retrieved
8 April 2019
stated in
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50750
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE CDK9 203198 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D042863
subject named as
Cyclin-Dependent Kinase 9
0 references
PDB structure ID
 
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