(Q44239831)

English

High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry

scientific article published in January 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

liquid chromatography-tandem mass spectrometry

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author name string

Samuel A Testino

1

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

Gabor Patonay

2

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

publication date

1 January 2003

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

Journal of Pharmaceutical and Biomedical Analysis

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Europe PubMed Central

PubMed publication ID

1 December 2017

30

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

1459-1467

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

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Detection of the enzymatic activity of cytochrome P-450 enzymes by high-performance liquid chromatography

1 reference

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Application of a generic fast gradient liquid chromatography tandem mass spectrometry method for the analysis of cytochrome P450 probe substrates

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Automated high throughput human CYP isoform activity assay using SPE-LC/MS method: application in CYP inhibition evaluation

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Validation of higher-throughput high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry assays to conduct cytochrome P450s CYP2D6 and CYP3A4 enzyme inhibition studies in human liver microsomes

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Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450

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High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1.

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High-throughput cytochrome P450 inhibition screening via cassette probe-dosing strategy. IV. Validation of a direct injection on-line guard cartridge extraction/tandem mass spectrometry method for simultaneous CYP3A4, 2D6 and 2E1 inhibition assessme

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

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Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential

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Effects of propofol on human hepatic microsomal cytochrome P450 activities.

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Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

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Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

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Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

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Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes

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Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

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Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man

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Identifiers

10.1016/S0731-7085(02)00480-6

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

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