(Q42284671)

19 October 2017

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes (English)

1 reference

19 October 2017

V A Eagling

1

1 reference

19 October 2017

J F Tjia

series ordinal

2

1 reference

19 October 2017

D J Back

series ordinal

3

1 reference

19 October 2017

language of work or name

English

0 references

publication date

1 February 1998

1 reference

British Journal of Clinical Pharmacology

19 October 2017

1 reference

19 October 2017

45

1 reference

19 October 2017

2

1 reference

19 October 2017

107-114

1 reference

Protein measurement with the Folin phenol reagent

19 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

In vitro methods for assessing human hepatic drug metabolism: their use in drug development

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

In vitro approaches can predict human drug metabolism

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Selective inhibitors of cytochromes P450.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Heterogeneity of cytochrome P450 and its toxicological significance

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Structural basis of selective cytochrome P450 inhibition

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Tolbutamide hydroxylation by human, rabbit and rat liver microsomes and by purified forms of cytochrome P-450

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Cytochromes P-450 in rats: structures, functions, properties and relevant human forms

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1873357

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

29 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1046%2FJ.1365-2125.1998.00679.X

Constitutive testosterone 6 beta-hydroxylase in rat liver

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

The effect of ketoconazole on hepatic oxidative drug metabolism in the rat in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Cytochrome P-450 2E1 is not the sole catalyst of chlorzoxazone hydroxylation in rat liver microsomes. off

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Putative active site template model for cytochrome P4502C9 (tolbutamide hydroxylase)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Molecular modelling of CYP1A subfamily members based on an alignment with CYP102: rationalization of CYP1A substrate specificity in terms of active site amino acid residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

Ketoconazole: a potent inhibitor of cytochrome P-450-dependent drug metabolism in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/9491822

12 December 2020

10.1046/J.1365-2125.1998.00679.X

Identifiers

DOI

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

9491822

1 reference