(Q38794109)

6 September 2017

title

Treating cancer with selective CDK4/6 inhibitors (English)

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6 September 2017

1

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author name string

Richard S Finn

series ordinal

2

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6 September 2017

Nicholas C Turner

series ordinal

3

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6 September 2017

language of work or name

English

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publication date

31 March 2016

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Nature Reviews Clinical Oncology

6 September 2017

published in

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6 September 2017

volume

13

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6 September 2017

issue

7

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6 September 2017

page(s)

417-430

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Genetic control of the cell division cycle in yeast

6 September 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

31 March 2020

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The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit

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Proliferation of cancer cells despite CDK2 inhibition.

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Cdk1 is sufficient to drive the mammalian cell cycle

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Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7

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cdk-7 Is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

31 March 2020

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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

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Phase I study of flavopiridol with oxaliplatin and fluorouracil/leucovorin in advanced solid tumors

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PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma

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Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation

31 March 2020

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Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression

31 March 2020

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Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

31 March 2020

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Requirement for CDK4 kinase function in breast cancer

31 March 2020

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Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer

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Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation

31 March 2020

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Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer

31 March 2020

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Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas

31 March 2020

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Distinct sets of genetic alterations in melanoma

31 March 2020

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Oncogene abnormalities in a series of primary melanomas of the sinonasal tract: NRAS mutations and cyclin D1 amplification are more frequent than KIT or BRAF mutations

31 March 2020

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The somatic genomic landscape of glioblastoma

31 March 2020

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Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.

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Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

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HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.

31 March 2020

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Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas.

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p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

31 March 2020

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Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

31 March 2020

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LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma

31 March 2020

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Sequencing of t(2;7) translocations reveals a consistent breakpoint linking CDK6 to the IGK locus in indolent B-cell neoplasia

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Molecular characterization of a t(2;7) translocation linking CDK6 to the IGK locus in CD5(-) monoclonal B-cell lymphocytosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Translocation t(2;7)(p11;q21) associated with the CDK6/IGK rearrangement is a rare but recurrent abnormality in B-cell lymphoproliferative malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16INK4A, P14ARF or cdk4 genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Germline p16 mutations in familial melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Cyclin D as a therapeutic target in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Repeated observation of breast tumor subtypes in independent gene expression data sets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Comprehensive molecular portraits of human breast tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

RB in breast cancer: at the crossroads of tumorigenesis and treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Cyclin-dependent kinase inhibitors as marketed anticancer drugs: where are we now? A short survey.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Semi-mechanistic pharmacokinetic/pharmacodynamic modeling of the antitumor activity of LY2835219, a new cyclin-dependent kinase 4/6 inhibitor, in mice bearing human tumor xenografts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Targeting cell cycle and hormone receptor pathways in cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Specific protection against breast cancers by cyclin D1 ablation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Treatment of growing teratoma syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

PD0332991 (palbociclib) for treatment of pediatric intracranial growing teratoma syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

miR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Treatment Rationale and Study Design for the JUNIPER Study: A Randomized Phase III Study of Abemaciclib With Best Supportive Care Versus Erlotinib With Best Supportive Care in Patients With Stage IV Non–Small-Cell Lung Cancer With a Detectable KRAS

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

A think tank of TINK/TANKs: tumor-infiltrating/tumor-associated natural killer cells in tumor progression and angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Tamoxifen-stimulated growth of breast cancer due to p21 loss

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Phase 1/2 study of cyclin-dependent kinase (CDK)4/6 inhibitor palbociclib (PD-0332991) with bortezomib and dexamethasone in relapsed/refractory multiple myeloma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Synthetic lethal therapy for KRAS mutant non-small-cell lung carcinoma with nanoparticle-mediated CDK4 siRNA delivery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Early G₁ cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRCLINONC.2016.26

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Saccharomyces cerevisiae cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Amplification and expression of the human cyclin D gene in esophageal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Determination of the prognostic value of cyclin D1 overexpression in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Rb and p16INK4a expression in resected non-small cell lung tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

Final overall survival: fulvestrant 500 mg vs 250 mg in the randomized CONFIRM trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/27030077

12 December 2020

10.1038/NRCLINONC.2016.26

Identifiers

DOI

1 reference

6 September 2017

1 reference