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Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition
scientific article published on 01 April 1999
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Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
title
Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
author name string
H S Zhang
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
A A Postigo
series ordinal
2
1 reference
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Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
D C Dean
series ordinal
3
1 reference
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Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
language of work or name
English
0 references
publication date
1 April 1999
1 reference
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Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
published in
Cell
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
volume
97
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
issue
1
1 reference
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Europe PubMed Central
PubMed publication ID
10199402
reference URL
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4 December 2019
page(s)
53-61
1 reference
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Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
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The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter
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E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity
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p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest
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7 January 2021
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E2F-1 functions in mice to promote apoptosis and suppress proliferation
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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
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Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene
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Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation
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E2F-5, a new E2F family member that interacts with p130 in vivo
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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts
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Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
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7 January 2021
based on heuristic
inferred from DOI database lookup
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
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Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2
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Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15
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7 January 2021
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Expression of transcription factor E2F1 induces quiescent cells to enter S phase
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7 January 2021
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Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.
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7 January 2021
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Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
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7 January 2021
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Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
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7 January 2021
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Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
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DP and E2F proteins: coordinating transcription with cell cycle progression.
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DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control
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7 January 2021
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inferred from DOI database lookup
The retinoblastoma protein binds to a family of E2F transcription factors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rb interacts with histone deacetylase to repress transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGFbeta signaling: receptors, transducers, and Mad proteins.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of DNA synthesis and apoptosis are separable functions of E2F-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor E2F-1 is a downstream target of RB action
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclins, Cdks, and cyclin kinase inhibitors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer cell cycles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of mammalian G1 cyclin-dependent kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct roles for cyclin-dependent kinases in cell cycle control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The retinoblastoma protein and cell cycle control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
E2F and cell proliferation: a world turned upside down
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoblastoma protein switches the E2F site from positive to negative element
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of active transcriptional repression by the retinoblastoma protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 and E2F-1 cooperate to mediate apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor induction and tissue atrophy in mice lacking E2F-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980714-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0092-8674(00)80714-X
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
PubMed publication ID
10199402
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10199402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
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