(Q77310904)

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4 December 2019

title

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition (English)

1 reference

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4 December 2019

author name string

H S Zhang

series ordinal

1

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4 December 2019

A A Postigo

series ordinal

2

1 reference

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4 December 2019

D C Dean

series ordinal

3

1 reference

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4 December 2019

language of work or name

English

0 references

publication date

1 April 1999

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4 December 2019

1 reference

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4 December 2019

volume

97

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4 December 2019

issue

1

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4 December 2019

page(s)

53-61

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The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter

4 December 2019

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p14ARF links the tumour suppressors RB and p53.

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7 January 2021

Retinoblastoma protein recruits histone deacetylase to repress transcription

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7 January 2021

Direct transcriptional repression by pRB and its reversal by specific cyclins

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7 January 2021

The E2F transcription factor is a cellular target for the RB protein

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7 January 2021

A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.

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7 January 2021

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity

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7 January 2021

The cell cycle and the retinoblastoma protein family

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7 January 2021

TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest

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7 January 2021

p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest

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Functional roles of E2F in cell cycle regulation

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7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

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7 January 2021

Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity

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7 January 2021

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

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7 January 2021

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene

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7 January 2021

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

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7 January 2021

E2F-5, a new E2F family member that interacts with p130 in vivo

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7 January 2021

Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

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7 January 2021

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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7 January 2021

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

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7 January 2021

Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2

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7 January 2021

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

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7 January 2021

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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7 January 2021

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

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7 January 2021

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

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7 January 2021

Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members

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7 January 2021

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

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7 January 2021

DP and E2F proteins: coordinating transcription with cell cycle progression.

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7 January 2021

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

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7 January 2021

The retinoblastoma protein binds to a family of E2F transcription factors

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7 January 2021

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

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7 January 2021

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

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7 January 2021

Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

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7 January 2021

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

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7 January 2021

Rb interacts with histone deacetylase to repress transcription

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7 January 2021

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

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7 January 2021

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7 January 2021

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

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7 January 2021

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

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7 January 2021

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

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7 January 2021

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

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7 January 2021

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

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7 January 2021

The transcription factor E2F-1 is a downstream target of RB action

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7 January 2021

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

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7 January 2021

Cyclins, Cdks, and cyclin kinase inhibitors.

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7 January 2021

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

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7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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7 January 2021

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

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7 January 2021

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7 January 2021

Inhibitors of mammalian G1 cyclin-dependent kinases

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7 January 2021

E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)

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7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

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7 January 2021

Distinct roles for cyclin-dependent kinases in cell cycle control

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7 January 2021

The retinoblastoma protein and cell cycle control

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7 January 2021

E2F and cell proliferation: a world turned upside down

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7 January 2021

Retinoblastoma protein switches the E2F site from positive to negative element

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7 January 2021

Mechanism of active transcriptional repression by the retinoblastoma protein

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7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

10.1016/S0092-8674(00)80714-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10199402%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference