(Q35944646)

11 August 2017

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. (English)

1 reference

11 August 2017

1 reference

S N Jones

1

1 reference

11 August 2017

A T Sands

2

1 reference

11 August 2017

A R Hancock

3

1 reference

11 August 2017

H Vogel

4

1 reference

11 August 2017

L A Donehower

5

1 reference

11 August 2017

S P Linke

6

1 reference

11 August 2017

G M Wahl

7

1 reference

11 August 2017

A Bradley

8

1 reference

11 August 2017

language of work or name

English

0 references

publication date

1 November 1996

1 reference

11 August 2017

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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11 August 2017

93

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11 August 2017

24

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11 August 2017

14106-14111

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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

mdm2 expression is induced by wild type p53 activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

The p53-mdm-2 autoregulatory feedback loop

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Interaction between the retinoblastoma protein and the oncoprotein MDM2

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

p53 deficiency does not affect the accumulation of point mutations in a transgene target

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Evidence for a second cell cycle block at G2/M by p53.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

p53 functions as a cell cycle control protein in osteosarcomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Amplification of a gene encoding a p53-associated protein in human sarcomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Cell cycle regulation of gene amplification

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Homozygous deletion of the retinoblastoma gene in an acute lymphoblastic leukemia (T) cell line.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19502

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.93.24.14106

Genetic background alters the spectrum of tumors that develop in p53-deficient mice

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

The human MDM-2 oncogene is overexpressed in leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

DNA damage increases the levels of MDM2 messenger RNA in wtp53 human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

A subset of p53-deficient embryos exhibit exencephaly

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

MDM2 gene amplification in metastatic osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

p53 Mutation and MDM2 amplification in human soft tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943068

12 December 2020

Identifiers

DOI

10.1073/PNAS.93.24.14106

1 reference

11 August 2017

0 references

1 reference

11 August 2017

PubMed publication ID

8943068

1 reference