(Q34770308)

4 August 2017

1 reference

title

The molecular and genetic basis of neurological tumours (English)

1 reference

4 August 2017

Yuan Zhu

1

1 reference

4 August 2017

Luis F Parada

series ordinal

2

1 reference

4 August 2017

language of work or name

English

0 references

publication date

1 August 2002

1 reference

4 August 2017

published in

Nature Reviews Cancer

1 reference

4 August 2017

volume

2

1 reference

4 August 2017

issue

8

1 reference

4 August 2017

page(s)

616-626

1 reference

Malignant glioma: genetics and biology of a grave matter.

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Gliomagenesis: genetic alterations and mouse models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

NF1 tumor suppressor gene function: narrowing the GAP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Neurofibromin, a tumor suppressor in the nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

31 March 2020

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

p53 mutation, expression, and DNA ploidy in evolving gliomas: evidence for two pathways of progression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

A case history of glioma progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Clonal expansion of p53 mutant cells is associated with brain tumour progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Lessons from hereditary colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Tumor spectrum analysis in p53-mutant mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Astrocytes derived from p53-deficient mice provide a multistep in vitro model for development of malignant gliomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Signaling--2000 and beyond

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

CNTF and its receptor subunits in human gliomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Developmental expression of platelet-derived growth factor alpha-receptor in neurons and glial cells of the mouse CNS.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Guidance of cell migration by the Drosophila PDGF/VEGF receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Proliferation of human malignant astrocytomas is dependent on Ras activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

To cycle or not to cycle: a critical decision in cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Role of the INK4a locus in tumor suppression and cell mortality.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Alterations of cell cycle regulatory genes in primary (de novo) and secondary glioblastomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

The INK4a/ARF network in tumour suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Association of EGFR Gene Amplification and CDKN2 (p16/MTS1) Gene Deletion in Glioblastoma Multiforme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Subsets of glioblastoma multiforme defined by molecular genetic analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Stem cells in the adult mammalian central nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Mammalian neural stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

The development of neural stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Adult neurogenesis in mammals: an identity crisis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Astrocytes give rise to new neurons in the adult mammalian hippocampus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Neurons derived from radial glial cells establish radial units in neocortex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Characterization of CNS precursor subtypes and radial glia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

A unified hypothesis on the lineage of neural stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Epidermal growth factor receptor and Ink4a/Arf

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Origin and early development of Schwann cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Loss of NF1 alleles in phaeochromocytomas from patients with type I neurofibromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Confirmation of a double-hit model for the NF1 gene in benign neurofibromas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Mouse models of tumor development in neurofibromatosis type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

TP53 mutations are frequent in malignant NF1 tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Mouse tumor model for neurofibromatosis type 1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Prediction of central nervous system embryonal tumour outcome based on gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Cancer gene therapy: fringe or cutting edge?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Tyrosine kinase inhibitors: from rational design to clinical trials

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Mechanism-based target identification and drug discovery in cancer research

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Anticancer drug targets: cell cycle and checkpoint control.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Glial cell diversification in the rat optic nerve

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Visualization of O-2A progenitor cells in developing and adult rat optic nerve by quisqualate-stimulated cobalt uptake

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Oligodendrocyte population dynamics and the role of PDGF in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

Comparative study of p53 gene and protein alterations in human astrocytic tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC866

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC866

1 reference

Dimensions Publication ID

4 August 2017

1019690281

0 references

1 reference