(Q34568715)

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8 December 2019

review article

1 reference

title

Interleukin-2 and interleukin-15: immunotherapy for cancer (English)

1 reference

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8 December 2019

0 references

1 reference

1

1 reference

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8 December 2019

author name string

Megan A Cooper

series ordinal

2

1 reference

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8 December 2019

Michael A Caligiuri

series ordinal

3

1 reference

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8 December 2019

publication date

1 April 2002

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Cytokine and Growth Factor Reviews

8 December 2019

published in

1 reference

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8 December 2019

volume

13

1 reference

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8 December 2019

issue

2

1 reference

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8 December 2019

page(s)

169-183

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The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells

8 December 2019

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7 January 2021

Interleukin 15: biology and relevance to human disease

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Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

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Lymphokines and the immune response: the central role of interleukin-2.

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Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells

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Expression of interleukin 2 receptors on activated human B cells

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Haemopoietic receptors and helical cytokines

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Structural design and molecular evolution of a cytokine receptor superfamily

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7 January 2021

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor

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7 January 2021

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

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7 January 2021

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

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7 January 2021

The IL-2 receptor complex: its structure, function, and target genes

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7 January 2021

The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis

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7 January 2021

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

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7 January 2021

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

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7 January 2021

Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes

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7 January 2021

Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain

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7 January 2021

Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain.

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7 January 2021

Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex

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7 January 2021

Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression

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7 January 2021

IL-2 signaling involves recruitment and activation of multiple protein tyrosine kinases by the IL-2 receptor

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7 January 2021

Signaling through the hematopoietic cytokine receptors.

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7 January 2021

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

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7 January 2021

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

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7 January 2021

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

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7 January 2021

IL-15/IL-15R alpha intracellular trafficking in human cells and protection from apoptosis.

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IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha

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Regulation of immune responses through inhibitory receptors

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7 January 2021

Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

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7 January 2021

Interleukin-1beta costimulates interferon-gamma production by human natural killer cells

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7 January 2021

Response of resting human peripheral blood natural killer cells to interleukin 2.

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7 January 2021

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

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7 January 2021

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

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7 January 2021

Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset

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7 January 2021

Selective modulation of human natural killer cells in vivo after prolonged infusion of low dose recombinant interleukin 2

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7 January 2021

Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors

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7 January 2021

Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo

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7 January 2021

Expression of a functional c-kit receptor on a subset of natural killer cells

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7 January 2021

Activation of natural killer cells via the p75 interleukin 2 receptor

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7 January 2021

A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells.

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7 January 2021

Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin

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7 January 2021

A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells

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7 January 2021

Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire

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7 January 2021

Mechanisms of genetic resistance to friend virus leukemia in mice

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7 January 2021

Production and differentiation of NK lineage cells in long-term bone marrow cultures in the absence of exogenous growth factors

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7 January 2021

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

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7 January 2021

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7 January 2021

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

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7 January 2021

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

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7 January 2021

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

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7 January 2021

Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain

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7 January 2021

Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency

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7 January 2021

Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems

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7 January 2021

A potential role for interleukin-15 in the regulation of human natural killer cell survival

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7 January 2021

CD56bright natural killer cell subsets: characterization of distinct functional responses to interleukin-2 and the c-kit ligand

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7 January 2021

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells

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7 January 2021

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

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7 January 2021

IL-15 and IL-2: a matter of life and death for T cells in vivo

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7 January 2021

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

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7 January 2021

Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.

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7 January 2021

Effects of the deregulated expression of human interleukin-2 in transgenic mice

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7 January 2021

Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

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7 January 2021

Extended continuous infusion low-dose recombinant interleukin-2 in advanced cancer: prolonged immunomodulation without significant toxicity

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7 January 2021

Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response

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7 January 2021

High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993

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7 January 2021

Low-dose interleukin 2 prevents the development of Epstein-Barr virus (EBV)-associated lymphoproliferative disease in scid/scid mice reconstituted i.p. with EBV-seropositive human peripheral blood lymphocytes

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7 January 2021

The clinical effects of prolonged treatment of patients with advanced cancer with low-dose subcutaneous interleukin-2 [corrected]

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7 January 2021

Evaluation of natural killer cell expansion and activation in vivo with daily subcutaneous low-dose interleukin-2 plus periodic intermediate-dose pulsing.

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7 January 2021

Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity

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7 January 2021

Defective natural immunity: an early manifestation of human immunodeficiency virus infection

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7 January 2021

Potential mechanisms of human natural killer cell expansion in vivo during low-dose IL-2 therapy

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7 January 2021

Rapid regression of chemotherapy refractory lymphocyte predominant Hodgkin's disease after administration of rituximab (anti CD 20 mono- clonal antibody) and interleukin-2.

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7 January 2021

Antibody-cytokine fusion proteins for the therapy of cancer

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7 January 2021

Targeted cytokines for cancer immunotherapy.

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7 January 2021

Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2

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7 January 2021

IL-15 Mediates Anti-tumor Effects after Cyclophosphamide Injection of Tumor-Bearing Mice and Enhances Adoptive Immunotherapy: The Potential Role of NK Cell Subpopulations

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7 January 2021

Control of homeostasis of CD8+ memory T cells by opposing cytokines.

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7 January 2021

A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus

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7 January 2021

Design and evaluation of antigen-specific vaccination strategies against cancer.

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7 January 2021

The dendritic cell and human cancer vaccines

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7 January 2021

10.1016/S1359-6101(01)00021-1

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11900992%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference