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Genetic engineering in mice: impact on insulin signalling and action.
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Europe PubMed Central
PMC publication ID
1219769
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
review article
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Europe PubMed Central
title
Genetic engineering in mice: impact on insulin signalling and action
(English)
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Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
main subject
preproinsulin
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inferred from title
author
Pierre De Meyts
series ordinal
6
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Europe PubMed Central
PMC publication ID
1219769
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
author name string
B Lamothe
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1
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Europe PubMed Central
PMC publication ID
1219769
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
A Baudry
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2
1 reference
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Europe PubMed Central
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1219769
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
P Desbois
series ordinal
3
1 reference
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Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
L Lamotte
series ordinal
4
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Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
D Bucchini
series ordinal
5
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Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
R L Joshi
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7
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Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
language of work or name
English
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publication date
1 October 1998
1 reference
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Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
published in
Biochemical Journal
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Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
volume
335 ( Pt 2)
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Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
page(s)
193-204
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stated in
Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
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Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue
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Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes
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Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.
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Transgenic approaches to the pathogenesis of NIDDM.
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Mechanisms of hormone resistance: lessons from insulin-resistant patients.
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Expression of human GLUT4 in mice results in increased insulin action
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6 July 2018
High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance
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Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: effect of exercise and role in glucose homeostasis
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The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.
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Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.
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High fat diet-induced hyperglycemia: prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice
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Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4).
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Role of IRS-2 in insulin and cytokine signalling
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6 July 2018
Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
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6 July 2018
Animal Model for Maturity-onset Diabetes of the Young Generated by Disruption of the Mouse Glucokinase Gene
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6 July 2018
A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cells
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6 July 2018
4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice
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6 July 2018
Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis
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6 July 2018
Mitogenic potential of insulin on lymphoma cells lacking IGF-1 receptor.
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6 July 2018
Mechanism of insulin and IGF-I receptor activation and signal transduction specificity. Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling
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6 July 2018
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Pancreatic expression of human insulin gene in transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Hyperinsulinemia in transgenic mice carrying multiple copies of the human insulin gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Insulin dependence of murine lymphoid T-cell leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
6 July 2018
Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Insulin stimulation of mitogen-activated protein kinase, p90rsk, and p70 S6 kinase in skeletal muscle of normal and insulin-resistant mice. Implications for the regulation of glycogen synthase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Expression of the gene encoding the tyrosine kinase-deficient human insulin receptor in transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Glucose transport activity in skeletal muscles from transgenic mice overexpressing GLUT1. Increased basal transport is associated with a defective response to diverse stimuli that activate GLUT4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Constitutive (pro)insulin release from pancreas of transgenic mice expressing monomeric insulin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1219769
retrieved
27 October 2018
Insulin decreases phosphoenolpyruvate carboxykinase (GTP) mRNA activity by a receptor-mediated process
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impaired insulin signaling in skeletal muscles from transgenic mice expressing kinase-deficient insulin receptors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Regulation of human insulin gene expression in transgenic mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Muscle-Specific Expression of Human Insulin Receptor in Transgenic Mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A new transgenic mouse model of chronic hyperglycemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Altering mice by homologous recombination using embryonic stem cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9761714
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1042/BJ3350193
1 reference
stated in
Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
Fatcat ID
release_n7be6tr6unbdrgeefyfldmbrau
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/n7be6tr6unbdrgeefyfldmbrau
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
PMC publication ID
1219769
1 reference
stated in
Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
PubMed publication ID
9761714
1 reference
stated in
Europe PubMed Central
PMC publication ID
1219769
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9761714%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
ResearchGate publication ID
13523784
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