(Q34315974)

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The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

1 reference

Europe PubMed Central

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

1 reference

based on heuristic

inferred from title

Pierre De Meyts

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

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P De Meyts

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

publication date

1 September 1994

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

37 Suppl 2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

S135-48

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and functional homologies in the receptors for insulin and the insulin-like growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of receptor occupancy, concentration differences, and ligand exchange in the insulin-like growth factor I receptor system

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rational design of potent antagonists to the human growth hormone receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the human insulin receptor gene and characterization of its promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative cooperativity in regulatory enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of the insulin superfamily: cloning of a hybrid insulin/insulin-like growth factor cDNA from amphioxus

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single chain des-(B30) insulin. Intramolecular crosslinking of insulin by trypsin catalyzed transpeptidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of 2Zn pig insulin crystals at 1.5 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormone binding site of the insulin receptor: analysis using photoaffinity-mediated avidin complexing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alphas, betas, and kinases of cytokine receptor complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin dependence of murine lymphoid T-cell leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by receptors with tyrosine kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I receptor gene structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of a new hormone contact site within the insulin receptor ectodomain by the use of a novel photoreactive insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of determinants that confer ligand specificity on the insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin receptor: structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of insuling and other hormones to non-receptor materials: Saturability, specificity and apparent “negative cooperativity”

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The interaction of insulin with its receptor: cross-linking via insulin association as the source of receptor clustering

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of a structural and a functional epitope

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis of negative co-operativity in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new interpretation of structure-function relationships in insulin-receptor interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin receptor. Structural basis for high affinity ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monomeric insulins and their experimental and clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating ("Ksuper") state of the insulin receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor binding redefined by a structural switch in a mutant human insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptor autophosphorylation occurs asymmetrically

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural basis for insulin-like growth factor I receptor high affinity binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An insulin-like growth factor I/insulin hybrid exhibiting high potency for interaction with the type I insulin-like growth factor and insulin receptors of placental plasma membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nonclassical insulin binding of insulin receptors from rat liver is due to the presence of two interacting alpha-subunits in the receptor complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How receptor tyrosine kinases activate Ras.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-site interactions among insulin receptors. Characterization of the negative cooperativity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired negative cooperativity of the semisynthetic analogues human [LeuB24]- and [LeuB25]-insulins

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormonal control of adipose-tissue lipolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immobilized insulin for high capacity affinity chromatography of insulin receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolutionary conservation of the insulin gene structure in invertebrates: cloning of the gene encoding molluscan insulin-related peptide III from Lymnaea stagnalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the insulin receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin interactions with its receptors: experimental evidence for negative cooperativity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding and biological effects of insulin, insulin analogues and insulin-like growth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for insulin binding to the insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormones, growth factors, and myogenic differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of Negative Cooperativity and Half-of-the-Sites Reactivity in Enzyme Regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of two insulin-binding components of rat-liver plasma membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin receptors are bivalent as demonstrated by photoaffinity labeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that insulin receptor from human placenta has a high affinity for only one molecule of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-parallel evolution of metabolic and growth-promoting functions of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and biological activity of hagfish insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin‐binding domain of insulin receptor is encoded by exon 2 and exon 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits*

1 reference

https://pubmed.ncbi.nlm.nih.gov/7821729

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00400837

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7821729%20AND%20SRC:MED&resulttype=core&format=json

26 October 2019

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