(Q29615644)

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

scientific article (publication date: 13 June 2003)

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Europe PubMed Central

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2 November 2019

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression (English)

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30 April 2017

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2 November 2019

Michael McMahon

1

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2 November 2019

4

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2 November 2019

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Ken Itoh

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2 November 2019

Masayuki Yamamoto

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2 November 2019

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30 April 2017

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7 April 2003

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2 November 2019

Journal of Biological Chemistry

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30 April 2017

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2 November 2019

278

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30 April 2017

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2 November 2019

24

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30 April 2017

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2 November 2019

21592-21600

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2 November 2019

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

1 reference

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Regulation of gene expression by reactive oxygen

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The heme-responsive element of the mouse heme oxygenase-1 gene is an extended AP-1 binding site that resembles the recognition sequences for MAF and NF-E2 transcription factors

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Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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21 January 2018

Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells

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Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

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Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

1 reference

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Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

1 reference

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

1 reference

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21 January 2018

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

1 reference

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21 January 2018

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

1 reference

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21 January 2018

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

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21 January 2018

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

1 reference

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21 January 2018

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

1 reference

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21 January 2018

Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

1 reference

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21 January 2018

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

1 reference

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21 January 2018

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

1 reference

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The ubiquitin system

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

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21 January 2018

Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis

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21 January 2018

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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21 January 2018

A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway

1 reference

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21 January 2018

Chemical and molecular regulation of enzymes that detoxify carcinogens

1 reference

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21 January 2018

Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK.

1 reference

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21 January 2018

Glutathione redox potential in response to differentiation and enzyme inducers.

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The ubiquitin-proteasome pathway: on protein death and cell life

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The proteasome: paradigm of a self-compartmentalizing protease

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Ubiquitin in chains

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The N-end rule: functions, mysteries, uses

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Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization

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Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4.

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Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.

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Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

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The kelch repeat superfamily of proteins: propellers of cell function

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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

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The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

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Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2

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21 January 2018

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10.1074/JBC.M300931200

3 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12682069

30 April 2017

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2 November 2019

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30 April 2017

Consolidated OpenCitations Corpus – April 2017

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2 November 2019

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