(Q28589094)

31 January 2017

title

LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection (English)

1 reference

Linker for activation of T cells

31 January 2017

main subject

1 reference

Lymphocyte protein tyrosine kinase

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Serine/threonine kinase 11

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Growth factor receptor bound protein 2

1 reference

Phospholipase C, gamma 1

1 reference

Lymphocyte cytosolic protein 2

1 reference

thymocyte

0 references

author name string

Yonghao Cao

1

1 reference

31 January 2017

Hai Li

2

1 reference

31 January 2017

Haifeng Liu

3

1 reference

31 January 2017

Min Zhang

4

1 reference

31 January 2017

Zichun Hua

5

1 reference

31 January 2017

Hongbin Ji

6

1 reference

31 January 2017

Xiaolong Liu

7

1 reference

31 January 2017

language of work or name

English

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publication date

18 May 2011

1 reference

31 January 2017

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31 January 2017

volume

30

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31 January 2017

issue

10

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31 January 2017

page(s)

2083–2093

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Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1

31 January 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

LKB1 modulates lung cancer differentiation and metastasis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Functional anatomy of T cell activation and synapse formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

RUNX proteins in transcription factor networks that regulate T-cell lineage choice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Signal initiation in T-cell receptor microclusters

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Investigating central tolerance with reaggregate thymus organ cultures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

LKB1 and AMPK maintain epithelial cell polarity under energetic stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The many paths to p38 mitogen-activated protein kinase activation in the immune system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

LKB1-dependent signaling pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Immunological synapse and microclusters: the site for recognition and activation of T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Thymocyte motility: mutants, movies and migration patterns.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Fuel feeds function: energy metabolism and the T-cell response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Lipid rafts and the initiation of T cell receptor signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

LKB1 kinase: master and commander of metabolism and polarity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Calcium signalling in lymphocytes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Positive and negative selection of T cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

T-cell development and the CD4-CD8 lineage decision

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The T-cell receptor signalosome: a dynamic structure with expanding complexity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

BCL-2 family: regulators of cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The nature of the peptide/MHC ligand involved in positive selection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The different roles of MHC class recognition in thymocyte CD4 versus CD8 lineage commitment and positive selection.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The effect of in vivo IL-7 deprivation on T cell maturation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

Activation events during thymic selection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The majority of CD4+8- thymocytes are functionally immature

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3098487

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte

3 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.116

An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.116

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.116

CD69 expression during selection and maturation of CD4+8+ thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.116

Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.116

Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.116

Establishment of efficient reaggregation culture system for gene transfection into immature T cells by retroviral vectors

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21487392

12 December 2020

Production, selection, and maturation of thymocytes with high surface density of TCR

1 reference

https://pubmed.ncbi.nlm.nih.gov/21487392

12 December 2020

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

1 reference

https://pubmed.ncbi.nlm.nih.gov/21487392

12 December 2020

The analysis of costimulatory receptor signaling cascades in normal T lymphocytes using in vitro gene transfer and reporter gene analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21487392

12 December 2020

Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/21487392

12 December 2020

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/21487392

12 December 2020

A novel genotyping strategy based on allele-specific inverse PCR for rapid and reliable identification of conditional FADD knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21487392

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2011.116

1 reference

1 reference

1 reference

1 reference