(Q34831201)

4 August 2017

1 reference

title

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice (English)

1 reference

4 August 2017

Alfred Singer

1

1 reference

4 August 2017

Stanley Adoro

series ordinal

2

1 reference

4 August 2017

Jung-Hyun Park

series ordinal

3

1 reference

4 August 2017

publication date

1 October 2008

1 reference

Nature Reviews Immunology

4 August 2017

published in

1 reference

4 August 2017

volume

8

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4 August 2017

issue

10

1 reference

4 August 2017

page(s)

788-801

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Thymus lineage commitment: a single switch

4 August 2017

cites work

1 reference

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Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development

8 July 2018

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Development of all CD4 T lineages requires nuclear factor TOX

8 July 2018

1 reference

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IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival

8 July 2018

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The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer

8 July 2018

1 reference

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The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells.

8 July 2018

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The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins

8 July 2018

1 reference

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Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.

8 July 2018

1 reference

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Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR

8 July 2018

1 reference

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Commitment issues: linking positive selection signals and lineage diversification in the thymus

8 July 2018

1 reference

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Role of the transcription factor Th-POK in CD4:CD8 lineage commitment

8 July 2018

1 reference

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Stat5a/b are essential for normal lymphoid development and differentiation

8 July 2018

1 reference

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Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

8 July 2018

1 reference

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CD4-CD8 lineage commitment: an inside view

8 July 2018

1 reference

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Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Functional and molecular analysis of the double-positive stage-specific CD8 enhancer E8III during thymocyte development.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Ikaros null mice display defects in T cell selection and CD4 versus CD8 lineage decisions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Structure and regulated expression of mammalian RUNX genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

TOX provides a link between calcineurin activation and CD8 lineage commitment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Critical roles for transcription factor GATA-3 in thymocyte development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

TOX: an HMG box protein implicated in the regulation of thymocyte selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Negative regulation of CD4 gene expression by a HES-1-c-Myb complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Tec family kinases modulate thresholds for thymocyte development and selection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The regulation of CD4 and CD8 coreceptor gene expression during T cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The notch pathway intermediate HES-1 silences CD4 gene expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Differential requirements for ZAP-70 in TCR signaling and T cell development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The influence of the MAPK pathway on T cell lineage commitment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Positive selection induces CD4 promoter and enhancer function.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Asynchronous coreceptor downregulation after positive thymic selection: prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

A transcriptional silencer controls the developmental expression of the CD4 gene.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Elf-1 binds to a critical element in a second CD4 enhancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Role of coreceptors in positive selection and lineage commitment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Stochastic component to development of class I major histocompatibility complex-specific T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Essential role for ZAP-70 in both positive and negative selection of thymocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Cell-cell adhesion mediated by CD8 and MHC class I molecules

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Interaction between CD4 and class II MHC molecules mediates cell adhesion

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

8 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Another view of the selective model of thymocyte selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Regulation of lineage commitment distinct from positive selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Lck activity controls CD4/CD8 T cell lineage commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

The role of erk1 and erk2 in multiple stages of T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

The CD8alpha gene locus is regulated by the Ikaros family of proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Analyzing expression of perforin, Runx3, and Thpok genes during positive selection reveals activation of CD8-differentiation programs by MHC II-signaled thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

HMG box containing transcription factors in lymphocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

How the T Cell Repertoire Becomes Peptide and MHC Specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2760737

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

26 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Accessories or coreceptors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Thymocytes control the CD4 gene differently from mature T lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2416

31 March 2020

Identifiers

DOI

10.1038/NRI2416

1 reference

4 August 2017

1 reference

4 August 2017

1 reference