(Q28512320)

25 January 2017

title

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport (English)

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

1 reference

1 reference

Presenilin 1

1 reference

Kinesin family member 5B

1 reference

Kinesin light chain 1

1 reference

Syntaxin 1A (brain)

1 reference

Glycogen synthase kinase 3 beta

1 reference

author name string

Gustavo Pigino

1

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

Gerardo Morfini

2

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

Alejandra Pelsman

3

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

Jorge Busciglio

6

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

Mark P Mattson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

Scott T Brady

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

language of work or name

English

0 references

publication date

1 June 2003

1 reference

25 January 2017

published in

Journal of Neuroscience

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

volume

23

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

issue

11

2 references

25 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

page(s)

4499-4508

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

12 May 2020

cites work

1 reference

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12 December 2020

Mitochondria in neurodegeneration: acute ischemia and chronic neurodegenerative diseases

1 reference

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12 December 2020

The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

1 reference

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12 December 2020

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice

1 reference

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12 December 2020

Motor dysfunction in mildly demented AD individuals without extrapyramidal signs.

1 reference

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12 December 2020

Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Release of kinesin from vesicles by hsc70 and regulation of fast axonal transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Motor function and disability in the dementias.

1 reference

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12 December 2020

Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

GSK3 beta forms a tetrameric complex with endogenous PS1-CTF/NTF and beta-catenin. Effects of the D257/D385A and FAD-linked mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Approaches to study interactions between kinesin motors and membranes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Glycogen synthase kinase-3beta regulates presenilin 1 C-terminal fragment levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Kinesin molecular motors: transport pathways, receptors, and human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Presenilin-1 and its N-terminal and C-terminal fragments are transported in the sciatic nerve of rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

GSK3 takes centre stage more than 20 years after its discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Regulation of kinesin: implications for neuronal development

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Activity level and balance in subjects with mild Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

A RIP tide in neuronal signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Characterization of neuronal dystrophy induced by fibrillar amyloid beta: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Fast axonal transport misregulation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Monoclonal antibodies to kinesin heavy and light chains stain vesicle-like structures, but not microtubules, in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Nerve growth cones isolated from fetal rat brain: subcellular fractionation and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Regulation and functions of the glycogen synthase kinase-3 subfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Intraneuronal compartments of the amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Protein topology of presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Light and electron microscopic localization of presenilin-1 in primate brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Immunochemical analysis of kinesin light chain function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Mechanisms of trafficking in axons and dendrites: implications for development and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

A role for cyclin-dependent kinase(s) in the modulation of fast anterograde axonal transport: effects defined by olomoucine and the APC tumor suppressor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Loss of motor units in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805290

12 December 2020

10.1523/JNEUROSCI.23-11-04499.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

OpenCitations bibliographic resource ID

12 May 2020

1187038

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740780&resulttype=core&format=json

12 May 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1187038