Wikidata

(Q21983050)

English

Glycogen synthase kinase 3 beta

mammalian protein found in Mus musculus

  • GSK-3 beta
  • glycogen synthase kinase-3 beta
  • serine/threonine-protein kinase GSK3B
  • 2.7.11.1
  • Gsk3b
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
19 references
retrieved
8 April 2019
stated in
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
retrieved
8 April 2019
stated in
Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IPI
protein serine/threonine kinase activity
determination method or standard
IEA
ISO
ISS
IDA
IMP
TAS
11 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
TAS
retrieved
8 April 2019
stated in
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
ISO
retrieved
8 April 2019
stated in
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IMP
retrieved
8 April 2019
stated in
SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IEA
retrieved
8 April 2019
stated in
DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA
retrieved
8 April 2019
stated in
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA
retrieved
8 April 2019
stated in
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA
retrieved
8 April 2019
stated in
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA
retrieved
8 April 2019
stated in
Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA
cell component
biological process
protein phosphorylation
determination method or standard
IDA
IGI
IEA
IMP
ISO
8 references
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
ISO
retrieved
8 April 2019
stated in
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
GOA
curator
UniProt
UniProt protein ID
Q9WV60
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IMP
retrieved
8 April 2019
stated in
Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IEA
retrieved
8 April 2019
stated in
The costimulation-regulated duration of PKB activation controls T cell longevity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA
retrieved
8 April 2019
stated in
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA
retrieved
8 April 2019
stated in
Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WV60
determination method or standard
IDA

Identifiers

 
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