(Q28389726)

English

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26212011%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer (English)

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20 February 2020

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20 February 2020

John E. Ladbury

20

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20 February 2020

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ORCID Public Data File 2021

Gordon B. Mills

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G B Mills

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20 February 2020

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Z Timsah

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20 February 2020

Z Ahmed

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20 February 2020

J Berrout

4

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20 February 2020

M Gagea

5

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20 February 2020

Y Zhou

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20 February 2020

G N A Pena

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20 February 2020

X Hu

8

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20 February 2020

C Vallien

9

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20 February 2020

C V Kingsley

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20 February 2020

Y Lu

11

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20 February 2020

J F Hancock

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20 February 2020

J Liu

13

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20 February 2020

A B Gladden

14

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20 February 2020

G Lopez-Berestein

16

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20 February 2020

M-C Hung

17

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20 February 2020

A K Sood

18

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20 February 2020

M Bogdanov

19

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20 February 2020

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27 July 2015

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20 February 2020

full work available at URL

http://eprints.whiterose.ac.uk/89027/

content deliverer

White Rose Research Online

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1 reference

Europe PubMed Central

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20 February 2020

35

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20 February 2020

17

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20 February 2020

2186-2196

1 reference

Europe PubMed Central

PMC publication ID

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20 February 2020

Inhibition of basal FGF receptor signaling by dimeric Grb2

1 reference

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20 March 2017

Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells

1 reference

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20 March 2017

Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

20 March 2017

Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

20 March 2017

Synthesis and function of 3-phosphorylated inositol lipids

1 reference

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20 March 2017

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

20 March 2017

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

20 March 2017

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

7 April 2017

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

7 April 2017

The functions and regulation of the PTEN tumour suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

7 April 2017

Endogenous viruses: insights into viral evolution and impact on host biology

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.279

22 April 2017

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

9 May 2017

Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters

1 reference

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29 September 2017

Targeting the PI3K-AKT-mTOR signaling network in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

29 September 2017

Accurate quantification of lipid species by electrospray ionization mass spectrometry - Meet a key challenge in lipidomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

29 September 2017

MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

29 September 2017

PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

29 September 2017

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

29 September 2017

Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis.

1 reference

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29 September 2017

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

1 reference

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29 September 2017

PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma

1 reference

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29 September 2017

PI3K/AKT/mTOR inhibitors in ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

29 September 2017

A role for AMPK in increased insulin action after serum starvation

1 reference

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29 September 2017

Inhibition of FGFR2 and FGFR1 increases cisplatin sensitivity in ovarian cancer

1 reference

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29 September 2017

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

29 September 2017

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

1 reference

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29 September 2017

FGFR2 as a molecular target in endometrial cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

29 September 2017

FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review).

1 reference

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29 September 2017

Phosphoinositide (PI) 3-kinase assays

1 reference

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29 September 2017

Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome

1 reference

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29 September 2017

Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells

1 reference

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29 September 2017

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

1 reference

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29 September 2017

Perturbations of the AKT signaling pathway in human cancer

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29 September 2017

Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane

1 reference

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29 September 2017

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

1 reference

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29 September 2017

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4792786

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Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses

1 reference

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2 June 2018

Serum starvation: caveat emptor

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2 June 2018

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

1 reference

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2 June 2018

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

1 reference

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2 June 2018

Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.279

21 January 2018

PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.279

21 January 2018

Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.279

21 January 2018

Determination of content and fatty acid composition of unlabeled phosphoinositide species by thin-layer chromatography and gas chromatography

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21 January 2018

Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays.

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27 November 2018

Identifiers

10.1038/ONC.2015.279

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26212011%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

10.1038/ONC.2015.279

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26212011%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26212011%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

2-s2.0-84937822650

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