(Q28211408)

10

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Fred Schaper

object named as

Fred Schaper

14

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author name string

Ute Lehmann

1

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Jochen Schmitz

2

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Manuela Weissenbach

3

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Radoslaw M Sobota

4

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Michael Hortner

5

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Kerstin Friederichs

6

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Iris Behrmann

7

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William Tsiaris

8

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Atsuo Sasaki

9

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Akihiko Yoshimura

11

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Benjamin G Neel

12

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Peter C Heinrich

Journal of Biological Chemistry

13

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language of work or name

English

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publication date

3 January 2003

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published in

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volume

278

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issue

1

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page(s)

661-71

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cites work

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1 reference

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Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells

21 January 2018

1 reference

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Impaired immune and acute-phase responses in interleukin-6-deficient mice.

21 January 2018

1 reference

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IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Acute-Phase Response Factor, a Nuclear Factor Binding to Acute-Phase Response Elements, is Rapidly Activated by Interleukin-6 at the Posttranslational Level

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Crystal structure of the tyrosine phosphatase SHP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

A new protein containing an SH2 domain that inhibits JAK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

A family of cytokine-inducible inhibitors of signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Structure and function of a new STAT-induced STAT inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Twenty proteins containing a C-terminal SOCS box form five structural classes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1/CIP1/SDI1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Structural and evolutionary relationships among protein tyrosine phosphatase domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Divergent roles of SHP-2 in ERK activation by leptin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210552200

21 January 2018

Identifiers

DOI

10.1074/JBC.M210552200

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12403768

1 reference

Consolidated OpenCitations Corpus – April 2017