(Q24297664)

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Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

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Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function (English)

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Ribosomal protein S7

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GOA release 2020-03-11

MDM2 proto-oncogene

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GOA release 2020-03-11

tumor protein p53

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GOA release 2020-03-11

negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

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GOA release 2020-03-11

author name string

D Chen

1

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Z Zhang

2

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M Li

3

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W Wang

4

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Y Li

5

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E R Rayburn

6

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D L Hill

7

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H Wang

8

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R Zhang

9

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language of work or name

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publication date

2 August 2007

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26

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35

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5029-37

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The role of p53 in tumour suppression: lessons from mouse models

1 reference

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Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

1 reference

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p53 represses ribosomal gene transcription

1 reference

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Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

1 reference

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Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

1 reference

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Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

1 reference

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Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis.

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

1 reference

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Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

1 reference

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Mdm2 promotes the rapid degradation of p53

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The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

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MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

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Cancer. p53, guardian of the genome

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MDM2--arbiter of p53's destruction

1 reference

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p53, the cellular gatekeeper for growth and division

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels

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DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.

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Regulation of HDM2 activity by the ribosomal protein L11

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Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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Unleashing the power of p53: lessons from mice and men.

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Yin Yang 1 is a negative regulator of p53.

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Surfing the p53 network

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Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed-backbone antisense oligonucleotides: in vitro and in vivo activities and mechanisms

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Interaction between the retinoblastoma protein and the oncoprotein MDM2

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Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

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Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms

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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

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