Wikidata

(Q21116037)

English

UPF3B regulator of nonsense mediated mRNA decay

mammalian protein found in Homo sapiens

  • nonfunctional UPF3B regulator of nonsense mediated mRNA decay
  • UPF3B
  • UPF3 regulator of nonsense transcripts homolog B
  • UPF3B pseudogene 2
  • hUpf3p-X
  • UPF3B pseudogene 3
  • mental retardation, X-linked 62
  • up-frameshift suppressor 3 homolog on chromosome X
  • UPF3B pseudogene 1
  • regulator of nonsense transcripts 3B
  • up-frameshift suppressor 3 homolog B
  • nonsense mRNA reducing factor 3B
  • hUpf3B
In more languages
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No label defined

No description defined

Statements

part of
nuclear pore
0 references
molecular function
protein binding
determination method or standard
IPI
19 references
retrieved
9 May 2019
stated in
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
eIF4G is required for the pioneer round of translation in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Disassembly of exon junction complexes by PYM
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
A protein interaction framework for human mRNA degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
A UPF3-mediated regulatory switch that maintains RNA surveillance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IPI
cell component
biological process
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
determination method or standard
NAS
IDA
TAS
IMP
IEA
5 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZI7&geneProductId=UniProtKB:Q9BZI7
determination method or standard
TAS
retrieved
17 October 2017
stated in
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZI7&geneProductId=UniProtKB:Q9BZI7
determination method or standard
NAS
retrieved
17 October 2017
stated in
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZI7&geneProductId=UniProtKB:Q9BZI7
determination method or standard
IMP
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZI7&geneProductId=UniProtKB:Q9BZI7
determination method or standard
IEA
retrieved
17 October 2017
stated in
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZI7&geneProductId=UniProtKB:Q9BZI7
determination method or standard
IDA
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
determination method or standard
IBA
IDA
IEA
IMP
NAS
TAS
7 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
TAS
retrieved
9 May 2019
stated in
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
NAS
retrieved
9 May 2019
stated in
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IEA
retrieved
9 May 2019
stated in
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
GOA
curator
UniProt
UniProt protein ID
Q9BZI7
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZI7
determination method or standard
IBA

Identifiers

 
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