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Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
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Europe PubMed Central
PubMed publication ID
11163187
reference URL
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3 November 2019
title
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
main subject
UPF3B regulator of nonsense mediated mRNA decay
1 reference
stated in
GOA release 2020-03-11
UPF3A regulator of nonsense mediated mRNA decay
1 reference
stated in
GOA release 2020-03-11
structural constituent of nuclear pore
1 reference
stated in
GOA release 2020-03-11
author
Jens Lykke-Andersen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
Joan A. Steitz
series ordinal
3
object named as
J A Steitz
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
author name string
M D Shu
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
language of work or name
English
0 references
publication date
1 December 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
published in
Cell
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
volume
103
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
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3 November 2019
issue
7
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
page(s)
1121-1131
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
cites work
Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Relationship between yeast polyribosomes and Upf proteins required for nonsense mRNA decay
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonsense mutations in the human beta-globin gene affect mRNA metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An essential component of the decapping enzyme required for normal rates of mRNA turnover
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
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7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Determination of mRNA fate by different RNA polymerase II promoters
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonsense-mediated mRNA decay in health and disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HuR binding to cytoplasmic mRNA is perturbed by heat shock
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modification of acidic residues normalizes sodium dodecyl sulfate-polyacrylamide gel electrophoresis of caldesmon and other proteins that migrate anomalously
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A perfect message: RNA surveillance and nonsense-mediated decay
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of mRNA surveillance in eukaryotes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Probing the structure of HIV-1 Rev by protein footprinting of multiple monoclonal antibody-binding sites
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of nonsense mutations on nuclear and cytoplasmic adenine phosphoribosyltransferase RNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutants of the bacteriophage MS2 coat protein that alter its cooperative binding to RNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of an additional gene required for eukaryotic nonsense mRNA turnover
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gene products that promote mRNA turnover in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nonsense surveillance in lymphocytes?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Premature translational termination triggers mRNA decapping
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian orthologues of a yeast regulator of nonsense transcript stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mRNA surveillance by the Caenorhabditis elegans smg genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Messenger RNA degradation in eukaryotes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular basis for dominantly inherited inclusion body beta-thalassemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binary specification of nonsense codons by splicing and cytoplasmic translation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900214-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0092-8674(00)00214-2
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1400787
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
OpenCitations bibliographic resource ID
1400787
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1400787
PubMed publication ID
11163187
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1400787
stated in
Europe PubMed Central
PubMed publication ID
11163187
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11163187%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 November 2019
ResearchGate publication ID
12167069
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