By leading the team of teachers and scholars of KPI at various stages of its formation they took the highest responsibility. The progress of the Institute depended on them.
| Kyrpychov Victor Lvovovych, the first Rector, Professor | 1898 - 1902 |  |
| Konovalov Mykhailo Ivanovych, Professor | 1902 - 1904 |  |
| Zvorykin Kostyantyn Oleksiyovych, Professor | 1904 - 1905 |  |
| Chyrvinsky Mykola Petrovych, elected rector, Professor | 1905 - 1906 |  |
| Tymofeev Volodymyr Fedorovych, Professor | 1906 - 1908 |  |
| Dementyev Kostyantyn Grygorovych, Professor | 1908 - 1911 |  |
| Zhukov Ivan Diomydovych, Professor | 1911 - 1917 |  |
| Yerchenko Petro Feofanovych, Professor | 1917 - 1919 |  |
| De-Metz Georhiy Georgiyovych, Professor | 1919 - 1920 |  |
| Stupin Oleksa Yakovych, e/d Rector, Professor | 1919 - 1920 |  |
| Veselovsky Sergiy Feofanovych, Professor | 1920 - 1921 |  |
| Kukharenko Ivan Antonovych, Professor | 03.1921 - 12.1921 |  |
| Bobrov Victorin Flavianovych, Professor | 1921 - 1929 |  |
| Melnykov Dmytro Fedorovych, Professor | 1929 - 1930 |  |
| Efimov Mykola Pylypovych, Professor | 1934 - 1936 |  |
| Zhikharev Pavlo Grygorovych, Professor | 12.1936-08.1937 | |
| Shpylko Mykola Pylypovych, Professor | 1937-1941 |  |
| Plygunov Oleksandr Sergiyovych, Professor | 1944-1952, 1955-1971 |  |
| Hrydnyev Vitaliy Nykyforovych, academician of Academy of Sciences of Ukrainian SSR | 1952 - 1955 |  |
| Shvets Ivan Trofyhymovych, academician of Academy of Sciences of Ukrainian SSR | 09.1955-12.1955 |  |
| Denisenko Grigoriy Ivanovych, corresponding member of Academy of Sciences of Ukrainian SSR | 1971 - 1987 |  |
| Talanchuk Petro Myhaylovych, Professor | 1987 - 1992 |  |
| Zgurovsky Mykhailo Zakharovych, academician of Academy of Sciences of Ukrainian SSR | 1992 - 2024 |  |
| Melnychenko Anatoly Anatoliyovych, professor | 2024 - |  |