MTOR

MTOR
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	4JT6, 1AUE, 1FAP, 1NSG, 2FAP, 2GAQ, 2NPU, 2RSE, 3FAP, 4DRH, 4DRI, 4DRJ, 4FAP, 4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 5FLC
Pengidentifikasi
Alias	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, mechanistic target of rapamycin, mechanistic target of rapamycin kinase
ID eksternal	OMIM: 601231 MGI: 1928394 HomoloGene: 3637 GeneCards: MTOR
Pola ekspresi RNA
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• protein domain specific binding; • TFIIIC-class transcription factor complex binding; • kinase activity; • ATP binding; • protein serine/threonine kinase activity; • transferase activity; • ribosome binding; • GO:0001948, GO:0016582 Ikatan protein plasma; • protein kinase binding; • nucleotide binding; • phosphoprotein binding; • protein kinase activity; • GO:0032403 protein-containing complex binding; • pengikatan protein identik; • translation regulator activity;
Komponen seluler	• sitoplasma; • sitosol; • phosphatidylinositol 3-kinase complex; • membran; • mitokondria; • TORC1 complex; • organelle membrane; • GO:0009327 protein-containing complex; • mitochondrial outer membrane; • Retikulum endoplasma; • TORC2 complex; • badan Golgi; • intracellular membrane-bounded organelle; • nucleoplasm; • soma; • PML body; • endoplasmic reticulum membrane; • Golgi membrane; • lysosomal membrane; • Dendrit; • Sistem endomembran; • Inti sel; • Lisosom; • glutamatergic synapse; • postsynaptic cytosol;
Proses biologis	• germ cell development; • positive regulation of protein phosphorylation; • response to amino acid; • positive regulation of lipid biosynthetic process; • positive regulation of actin filament polymerization; • positive regulation of skeletal muscle hypertrophy; • positive regulation of granulosa cell proliferation; • regulation of carbohydrate utilization; • post-embryonic development; • positive regulation of dendritic spine development; • positive regulation of translation; • positive regulation of eating behavior; • protein phosphorylation; • mRNA stabilization; • cell projection organization; • regulation of glycogen biosynthetic process; • positive regulation of cell growth involved in cardiac muscle cell development; • positive regulation of neuron maturation; • positive regulation of glial cell proliferation; • respons seluler terhadap hipoksia; • negative regulation of cell size; • response to cocaine; • positive regulation of protein kinase B signaling; • cardiac muscle contraction; • maternal process involved in female pregnancy; • ruffle organization; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • cardiac muscle cell development; • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; • regulation of membrane permeability; • response to insulin; • regulation of myelination; • regulation of fatty acid beta-oxidation; • regulation of osteoclast differentiation; • positive regulation of cholangiocyte proliferation; • regulation of protein kinase B signaling; • spinal cord development; • positive regulation of peptidyl-tyrosine phosphorylation; • perilaku sosial; • protein autophosphorylation; • negative regulation of cholangiocyte apoptotic process; • regulation of brown fat cell differentiation; • regulation of protein kinase activity; • GO:0033128 negative regulation of protein phosphorylation; • positive regulation of oligodendrocyte differentiation; • regulation of carbohydrate metabolic process; • regulation of actin cytoskeleton organization; • voluntary musculoskeletal movement; • Fosforilasi; • multicellular organism growth; • negative regulation of muscle atrophy; • wound healing; • positive regulation of neurogenesis; • response to morphine; • positive regulation of sensory perception of pain; • GO:0044257 Katabolisme protein; • 'de novo' pyrimidine nucleobase biosynthetic process; • cellular response to nutrient levels; • energy reserve metabolic process; • peptidyl-threonine phosphorylation; • positive regulation of transcription by RNA polymerase III; • positive regulation of smooth muscle cell proliferation; • visual learning; • positive regulation of myotube differentiation; • positive regulation of cell death; • positive regulation of endothelial cell proliferation; • negative regulation of iodide transmembrane transport; • cardiac muscle tissue development; • positive regulation of nitric oxide biosynthetic process; • regulation of response to food; • heart morphogenesis; • positive regulation of neuron death; • cardiac cell development; • negative regulation of protein ubiquitination; • brain development; • GO:1901313 positive regulation of gene expression; • long-term memory; • heart valve morphogenesis; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of neuron projection development; • regulation of cellular response to heat; • positive regulation of lamellipodium assembly; • positive regulation of stress fiber assembly; • GO:0072468 signal transduction; • regulation of protein phosphorylation; • negative regulation of macroautophagy; • anoikis; • TOR signaling; • GO:0100026 Reparasi DNA; • regulation of cell size; • negative regulation of autophagy; • positive regulation of epithelial to mesenchymal transition; • regulation of macroautophagy; • cellular response to amino acid starvation; • positive regulation of keratinocyte migration; • cellular response to amino acid stimulus; • cellular response to leucine; • positive regulation of wound healing, spreading of epidermal cells; • cellular response to leucine starvation; • cellular response to starvation; • TORC1 signaling; • Pertumbuhan tanaman; • regulation of cell growth; • response to nutrient; • activation of protein kinase B activity; • T-helper 1 cell lineage commitment; • response to activity; • positive regulation of phosphoprotein phosphatase activity; • negative regulation of calcineurin-NFAT signaling cascade; • regulation of translation at synapse, modulating synaptic transmission; • positive regulation of cytoplasmic translational initiation; • response to nutrient levels;
	Sumber:Amigo / QuickGO
Ortolog
	2475
	56717
	ENSG00000198793
	ENSMUSG00000028991
	P42345
	Q9JLN9
	NM_004958; NM_001386500; NM_001386501
	NM_020009
	NP_004949
	NP_064393
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

MTOR adalah berkas genetik pada kromosom 1 lokasi 1p36.2 dengan ekspresi berupa enzim jenis kinase dengan aktivitas enzimatik yang terkait dengan keluarga enzim fosfatidil inositol kinase, termasuk serina/treonina kinase.^[3]

Rujukan

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-03.

Artikel bertopik gen ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] (Inggris) "MTOR mechanistic target of rapamycin (serine/threonine kinase) [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-11-03.

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