DOI:10.1038/s41598-019-54159-1
Welcome to the repository of the mitochondrial morphology project. This repository contains all the final code used for this publication, for the simulations and images in the paper. Other material as the electron tomogram used to generate the meshes, and the meshes themselves can be found here.
For this publication we performed four computational experiments. In the folder mcell
you can find the code for the spatial MCell simulations, each experiment has its own directory. The names of the experiments are the same as in the publication. Three different spatial configurations of the proteins were explore they corresponds to the directories cristae
, ibm
and both
. In the folder odes_and_figures
is the code use to run the space-independent ordinary differential equation (ODE) approach, as before each experiment has its own directory. These scripts are written in Python 3. Depending on the code you want to run the software required, please refer to the section Installation for details.
Spatiotemporal simulations were performed with MCell (version 3.4). The corresponding ODEs were integrated with PyDSTool (version 0.88), and the following python libraries were also use for analysis and to produce the figures: Numpy (version 1.18.1) and Matplotlib (version 3.2.0).