SMAD7

SMAD7
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 2DJY, 2LTV, 2LTW, 2LTX, 2LTY, 2LTZ, 2KXQ
Identifiants
Aliases	SMAD7
IDs externes	OMIM: 602932 MGI: 1100518 HomoloGene: 4314 GeneCards: SMAD7
Position du gène (Homme) Chr. Chromosome 18 humain Locus 18q21.1 Début 48,919,853 bp Fin 48,950,965 bp
Position du gène (Souris) Chr. Chromosome 18 (souris) Locus 18|18 E3 Début 75,500,600 bp Fin 75,529,006 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans artère poplitée Tibial arteries Veine saphène Descending thoracic aorta auricule droit aorte ascendante cardiac muscle tissue of right atrium poumon droit artère coronaire gauche artère coronaire droite Fortement exprimé dans molaire gastrula left lung lobe antre du pylore crête génitale Caduque basale cumulus cell lumbar subsegment of spinal cord substantia nigra sang Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire liaison ADN beta-catenin binding type I transforming growth factor beta receptor binding collagen binding I-SMAD binding activin binding DNA-binding transcription factor activity liaison ion métal liaison protéique ubiquitin protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific Composant cellulaire cytoplasme centrosome transcription regulator complex membrane plasmique intracellulaire nucléoplasme catenin complex noyau fibrillar center cytosol complexe macromoléculaire Processus biologique cellular response to transforming growth factor beta stimulus regulation of ventricular cardiac muscle cell membrane depolarization pathway-restricted SMAD protein phosphorylation ureteric bud development regulation of transcription, DNA-templated adherens junction assembly positive regulation of cell-cell adhesion ventricular septum morphogenesis regulation of epithelial to mesenchymal transition negative regulation of peptidyl-threonine phosphorylation negative regulation of transcription by competitive promoter binding response to laminar fluid shear stress protein stabilization regulation of activin receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway BMP signaling pathway negative regulation of DNA-binding transcription factor activity negative regulation of pathway-restricted SMAD protein phosphorylation negative regulation of BMP signaling pathway ventricular cardiac muscle tissue morphogenesis negative regulation of protein ubiquitination negative regulation of cell migration negative regulation of ubiquitin-protein transferase activity artery morphogenesis negative regulation of peptidyl-serine phosphorylation regulation of cardiac muscle contraction positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of epithelial to mesenchymal transition positive regulation of transcription by RNA polymerase II regulation of transforming growth factor beta receptor signaling pathway transcription, DNA-templated transforming growth factor beta receptor signaling pathway protein deubiquitination negative regulation of T cell cytokine production negative regulation of T-helper 17 type immune response negative regulation of T-helper 17 cell differentiation cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 4092 17131 Ensembl ENSG00000101665 ENSMUSG00000025880 UniProt O15105 O35253 RefSeq (mRNA) NM_005904 NM_001190821 NM_001190822 NM_001190823 NM_001042660 NM_008543 RefSeq (protéine) NP_001177750 NP_001177751 NP_001177752 NP_005895 NP_001036125 Localisation (UCSC) Chr 18: 48.92 – 48.95 Mb Chr 18: 75.5 – 75.53 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

Le SMAD7 (ou Mothers against decapentaplegic homolog 7) est une protéine dont le gène est SMAD7 situé sur le chromosome 18 humain.

Rôle

Il inhibe le facteur de croissance transformant TGF-β1.

Cible thérapeutique

Le mongersen est un oligonucléotide se fixant sur l'ARN messager du SMAD7, facilitant sa dégradation. Donné par voie orale aux patients porteurs d'une maladie de Crohn, il en améliore les durées de rémission et les symptômes.