FGR
ظاهر
هومولوگ سرطانزای سارکومای ویروسی گربهسانان گاردنر-راشد (انگلیسی: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) یک پروتئین است که در انسان توسط ژن «FGR» کُدگذاری میشود.[۴][۵]
این پروتئین یکی از اعضای خانواده کینازهای Src است و در غشاء سلولی جای دارد و کوچ یاخته و چسبندگی سلولی ناشی از اینتگرینها را کاهش میدهد.
عفونت با ویروس اپشتین–بار موجب افزایش بیان ژنی این پروتئین میگردد.
این ژن در گربهسانان و توسط تیم تحقیقاتی ثریا راشد و موری گاردنر کشف شد.[۶]
منابع
[ویرایش]- ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028874 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "of Sciences of the United States of America". 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
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(help) - ↑ "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".
- ↑ Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.
- مشارکتکنندگان ویکیپدیا. «FGR (gene)». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲۴ اوت ۲۰۱۹.
برای مطالعهٔ بیشتر
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