فاکتور پاسخ سرم

SRF
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1HBX, 1K6O, 1SRS
معین‌کننده‌ها
نام‌های دیگر	SRF, MCM1, serum response factor
شناسه‌های بیرونی	OMIM: 600589 MGI: 106658 HomoloGene: 31135 GeneCards: SRF
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۷ (موش)
پایان	46,867,101 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein dimerization activity; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0000983 RNA polymerase II general transcription initiation factor activity; • primary miRNA binding; • transcription factor binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • protein homodimerization activity; • serum response element binding; • chromatin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • DNA binding; • sequence-specific DNA binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • chromatin DNA binding; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding; • RNA polymerase II-specific DNA-binding transcription factor binding;
ترکیبات سلولی	• سیتوپلاسم; • هسته یاخته; • نوکلئوپلاسم;
فرایند زیستی	• dorsal aorta morphogenesis; • bronchus cartilage development; • muscle cell cellular homeostasis; • lung smooth muscle development; • regulation of water loss via skin; • transcription by RNA polymerase II; • stress fiber assembly; • cell migration involved in sprouting angiogenesis; • platelet activation; • cardiac myofibril assembly; • heart looping; • پیرشدگی سلول; • face development; • regulation of cell adhesion; • long-term depression; • neuron projection development; • morphogenesis of an epithelial sheet; • positive regulation of filopodium assembly; • primitive streak formation; • cellular response to glucose stimulus; • negative regulation of cell population proliferation; • response to cytokine; • GO:0009373 regulation of transcription, DNA-templated; • heart trabecula formation; • actin filament organization; • thymus development; • angiogenesis involved in wound healing; • ترومبوپوئز; • neuron development; • in utero embryonic development; • transcription, DNA-templated; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • heart development; • positive regulation of cell differentiation; • branching involved in blood vessel morphogenesis; • positive regulation of axon extension; • positive regulation of smooth muscle contraction; • trachea cartilage development; • response to toxic substance; • positive regulation of pri-miRNA transcription by RNA polymerase II; • positive regulation of transcription by glucose; • regulation of smooth muscle cell differentiation; • epithelial structure maintenance; • associative learning; • skin morphogenesis; • positive regulation of DNA-binding transcription factor activity; • epithelial cell-cell adhesion; • neuron migration; • positive regulation of transcription initiation from RNA polymerase II promoter; • eyelid development in camera-type eye; • thyroid gland development; • negative regulation of amyloid-beta clearance; • negative regulation of cell migration; • developmental growth; • hematopoietic stem cell differentiation; • لایه‌زایی; • trophectodermal cell differentiation; • positive thymic T cell selection; • response to hormone; • cell-matrix adhesion; • sarcomere organization; • actin cytoskeleton organization; • megakaryocyte development; • response to hypoxia; • lung morphogenesis; • mesoderm formation; • cardiac vascular smooth muscle cell differentiation; • mRNA transcription by RNA polymerase II; • multicellular organism development; • tangential migration from the subventricular zone to the olfactory bulb; • حافظه بلندمدت; • contractile actin filament bundle assembly; • bicellular tight junction assembly; • leukocyte differentiation; • hippocampus development; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • erythrocyte development; • negative regulation of pri-miRNA transcription by RNA polymerase II; • forebrain development; • cell-cell adhesion;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6722
	20807
	ENSG00000112658
	ENSMUSG00000015605
	P11831
	Q9JM73
	NM_001292001، XM_047419268 NM_003131، NM_001292001، XM_047419268
	XM_006523957، XM_011246336 NM_020493، XM_006523957، XM_011246336
	NP_003122 NP_001278930، NP_003122; NP_003122.1
	XP_006524020، XP_011244638 NP_065239، XP_006524020، XP_011244638
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور پاسخ سرم(به انگلیسی: Serum response factor) که با نام SRF نیز شناخته می شود، یک پروتئین فاکتور رونویسی است.^[۴]

اهمیت بالینی

فقدان SRF پوست با پسوریازیس و سایر بیماری های پوستی مرتبط است.^[۵]

فعل و انفعالات

فاکتور پاسخ سرم با پروتئین های زیر تعامل پروتئین-پروتئین دارد:

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000015605 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Norman C, Runswick M, Pollock R, Treisman R (December 1988). "Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element". Cell. 55 (6): 989–1003. doi:10.1016/0092-8674(88)90244-9. PMID 3203386.
↑ Koegel H, von Tobel L, Schäfer M, Alberti S, Kremmer E, Mauch C, Hohl D, Wang XJ, Beer HD, Bloch W, Nordheim A, Werner S (April 2009). "Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice". J. Clin. Invest. 119 (4): 899–910. doi:10.1172/JCI37771. PMC 2662566. PMID 19307725.
↑ Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (July 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/mcb.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
↑ ^۷٫۰ ^۷٫۱ Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. doi:10.1128/MCB.17.9.4957. PMC 232347. PMID 9271374.
↑ Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta". J. Biol. Chem. 274 (20): 14224–8. doi:10.1074/jbc.274.20.14224. PMID 10318842.
↑ Sealy L, Malone D, Pawlak M (March 1997). "Regulation of the cfos serum response element by C/EBPbeta". Mol. Cell. Biol. 17 (3): 1744–55. doi:10.1128/mcb.17.3.1744. PMC 231899. PMID 9032301.
↑ ^۱۰٫۰ ^۱۰٫۱ Matsuzaki K, Minami T, Tojo M, Honda Y, Saitoh N, Nagahiro S, Saya H, Nakao M (March 2003). "PML-nuclear bodies are involved in cellular serum response". Genes Cells. 8 (3): 275–86. doi:10.1046/j.1365-2443.2003.00632.x. PMID 12622724. S2CID 9697837.
↑ Hassler M, Richmond TJ (June 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.
↑ Belaguli NS, Sepulveda JL, Nigam V, Charron F, Nemer M, Schwartz RJ (October 2000). "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators". Mol. Cell. Biol. 20 (20): 7550–8. doi:10.1128/mcb.20.20.7550-7558.2000. PMC 86307. PMID 11003651.
↑ Morin S, Paradis P, Aries A, Nemer M (February 2001). "Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor". Mol. Cell. Biol. 21 (4): 1036–44. doi:10.1128/MCB.21.4.1036-1044.2001. PMC 99558. PMID 11158291.
↑ Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode:1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423. S2CID 47196160.
↑ Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi:10.1016/S0021-9258(17)41889-8. PMID 8106390.
↑ Grueneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M (October 1997). "A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes Dev. 11 (19): 2482–93. doi:10.1101/gad.11.19.2482. PMC 316568. PMID 9334314.
↑ Kim DW, Cheriyath V, Roy AL, Cochran BH (June 1998). "TFII-I enhances activation of the c-fos promoter through interactions with upstream elements". Mol. Cell. Biol. 18 (6): 3310–20. doi:10.1128/mcb.18.6.3310. PMC 108912. PMID 9584171.
↑ Groisman R, Masutani H, Leibovitch MP, Robin P, Soudant I, Trouche D, Harel-Bellan A (March 1996). "Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins". J. Biol. Chem. 271 (9): 5258–64. doi:10.1074/jbc.271.9.5258. PMID 8617811.
↑ Biesiada E, Hamamori Y, Kedes L, Sartorelli V (April 1999). "Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter". Mol. Cell. Biol. 19 (4): 2577–84. doi:10.1128/MCB.19.4.2577. PMC 84050. PMID 10082523.
↑ Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. 460 (1): 41–5. doi:10.1016/s0014-5793(99)01311-3. PMID 10571058. S2CID 28576187.
↑ Lee SK, Kim JH, Lee YC, Cheong J, Lee JW (April 2000). "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor". J. Biol. Chem. 275 (17): 12470–4. doi:10.1074/jbc.275.17.12470. PMID 10777532.
↑ Kim HJ, Kim JH, Lee JW (October 1998). "Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations". J. Biol. Chem. 273 (44): 28564–7. doi:10.1074/jbc.273.44.28564. PMID 9786846.
↑ Gupta M, Kogut P, Davis FJ, Belaguli NS, Schwartz RJ, Gupta MP (March 2001). "Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1". J. Biol. Chem. 276 (13): 10413–22. doi:10.1074/jbc.M008625200. PMID 11136726.

جهت مطالعه

Esnault C, Stewart A, Gualdrini F, East P, Horswell S, Matthews N, Treisman R (May 2014). "Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts". Genes & Development. 28 (9): 943–58. doi:10.1101/gad.239327.114. PMC 4018493. PMID 24732378.
Huh S, Song HR, Jeong GR, Jang H, Seo NH, Lee JH, Lee TH (Feb 2018). "Suppression of the ERK–SRF axis facilitates somatic cell reprogramming". Experimental & Molecular Medicine. 50 (2): e448. doi:10.1038/emm.2017.279. PMC 5903827. PMID 29472703.
Pellegrino R, Thavamani A, Calvisi DF, Budczies J, Neumann A, Geffers R, et al. (January 2021). "Serum Response Factor (SRF) Drives the Transcriptional Upregulation of the MDM4 Oncogene in HCC". Cancers. 13 (2): 199. doi:10.3390/cancers13020199. PMC 7829828. PMID 33429878.
Hu X, Wu Q, Zhang J, Kim J, Chen X, Hartman AA, et al. (January 2021). "Reprogramming progressive cells display low CAG promoter activity". Stem Cells. 39 (1): 43–54. doi:10.1002/stem.3295. PMC 7821215. PMID 33075202.
Kepser LJ, Khudayberdiev S, Hinojosa LS, Macchi C, Ruscica M, Marcello E, et al. (February 2021). "Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts". Scientific Reports. 11 (1): 4789. Bibcode:2021NatSR..11.4789K. doi:10.1038/s41598-021-84213-w. PMC 7910472. PMID 33637797.

پیوند به بیرون

Serum Response Factor در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
SRF در دانشنامهٔ اجزای دی‌ان‌ای

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000015605 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3203386-4] Norman C, Runswick M, Pollock R, Treisman R (December 1988). "Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element". Cell. 55 (6): 989–1003. doi:10.1016/0092-8674(88)90244-9. PMID 3203386.

[pmid19307725-5] Koegel H, von Tobel L, Schäfer M, Alberti S, Kremmer E, Mauch C, Hohl D, Wang XJ, Beer HD, Bloch W, Nordheim A, Werner S (April 2009). "Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice". J. Clin. Invest. 119 (4): 899–910. doi:10.1172/JCI37771. PMC 2662566. PMID 19307725.

[pmid12077347-6] Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (July 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Mol. Cell. Biol. 22 (14): 5203–11. doi:10.1128/mcb.22.14.5203-5211.2002. PMC 139772. PMID 12077347.

[pmid9271374-7] ۷٫۰ ^۷٫۱ Zhu C, Johansen FE, Prywes R (September 1997). "Interaction of ATF6 and serum response factor". Mol. Cell. Biol. 17 (9): 4957–66. doi:10.1128/MCB.17.9.4957. PMC 232347. PMID 9271374.

[pmid10318842-8] Hanlon M, Sealy L (May 1999). "Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta". J. Biol. Chem. 274 (20): 14224–8. doi:10.1074/jbc.274.20.14224. PMID 10318842.

[pmid9032301-9] Sealy L, Malone D, Pawlak M (March 1997). "Regulation of the cfos serum response element by C/EBPbeta". Mol. Cell. Biol. 17 (3): 1744–55. doi:10.1128/mcb.17.3.1744. PMC 231899. PMID 9032301.

[pmid12622724-10] ۱۰٫۰ ^۱۰٫۱ Matsuzaki K, Minami T, Tojo M, Honda Y, Saitoh N, Nagahiro S, Saya H, Nakao M (March 2003). "PML-nuclear bodies are involved in cellular serum response". Genes Cells. 8 (3): 275–86. doi:10.1046/j.1365-2443.2003.00632.x. PMID 12622724. S2CID 9697837.

[pmid11406578-11] Hassler M, Richmond TJ (June 2001). "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. doi:10.1093/emboj/20.12.3018. PMC 150215. PMID 11406578.

[pmid11003651-12] Belaguli NS, Sepulveda JL, Nigam V, Charron F, Nemer M, Schwartz RJ (October 2000). "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators". Mol. Cell. Biol. 20 (20): 7550–8. doi:10.1128/mcb.20.20.7550-7558.2000. PMC 86307. PMID 11003651.

[pmid11158291-13] Morin S, Paradis P, Aries A, Nemer M (February 2001). "Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor". Mol. Cell. Biol. 21 (4): 1036–44. doi:10.1128/MCB.21.4.1036-1044.2001. PMC 99558. PMID 11158291.

[pmid7854423-14] Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode:1995Natur.373..632J. doi:10.1038/373632a0. PMID 7854423. S2CID 47196160.

[pmid8106390-15] Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi:10.1016/S0021-9258(17)41889-8. PMID 8106390.

[pmid9334314-16] Grueneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M (October 1997). "A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes Dev. 11 (19): 2482–93. doi:10.1101/gad.11.19.2482. PMC 316568. PMID 9334314.

[pmid9584171-17] Kim DW, Cheriyath V, Roy AL, Cochran BH (June 1998). "TFII-I enhances activation of the c-fos promoter through interactions with upstream elements". Mol. Cell. Biol. 18 (6): 3310–20. doi:10.1128/mcb.18.6.3310. PMC 108912. PMID 9584171.

[pmid8617811-18] Groisman R, Masutani H, Leibovitch MP, Robin P, Soudant I, Trouche D, Harel-Bellan A (March 1996). "Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins". J. Biol. Chem. 271 (9): 5258–64. doi:10.1074/jbc.271.9.5258. PMID 8617811.

[pmid10082523-19] Biesiada E, Hamamori Y, Kedes L, Sartorelli V (April 1999). "Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter". Mol. Cell. Biol. 19 (4): 2577–84. doi:10.1128/MCB.19.4.2577. PMC 84050. PMID 10082523.

[pmid10571058-20] Yamada K, Osawa H, Granner DK (October 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. 460 (1): 41–5. doi:10.1016/s0014-5793(99)01311-3. PMID 10571058. S2CID 28576187.

[pmid10777532-21] Lee SK, Kim JH, Lee YC, Cheong J, Lee JW (April 2000). "Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor". J. Biol. Chem. 275 (17): 12470–4. doi:10.1074/jbc.275.17.12470. PMID 10777532.

[pmid9786846-22] Kim HJ, Kim JH, Lee JW (October 1998). "Steroid receptor coactivator-1 interacts with serum response factor and coactivates serum response element-mediated transactivations". J. Biol. Chem. 273 (44): 28564–7. doi:10.1074/jbc.273.44.28564. PMID 9786846.

[pmid11136726-23] Gupta M, Kogut P, Davis FJ, Belaguli NS, Schwartz RJ, Gupta MP (March 2001). "Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1". J. Biol. Chem. 276 (13): 10413–22. doi:10.1074/jbc.M008625200. PMID 11136726.

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