User:Neuron2000/Agouti-related peptide
New Section: Role in Hunger Circuitry
- Mark L. Andermann and Bradford B. Lowell, two prominent scientist in the field say:
"...AgRP neurons and the wiring diagram within which they operate can be viewed as the physical embodiment of the intervening variable, hunger." (1)
- This is because stimulation of these neurons can induce robust feeding behavior, in many contexts:
- actual food consumption (2)
- willingness to work for food (3)
- investigating food odors (4)
- But they are rapidly inhibited upon presentation of food and actual feeding (5)
- These neurons signal with the inhibitor neurotransmitter Neuropeptide Y to sustain feeding (6)
- Are sensitive to hunger signals:
- ghrelin is an appetite stimulant, and it increases AGRP activity (7)
- leptin is a satiety signal, it decreases AGRP activity (8)
Sources (Not formatted yet):
https://www.cell.com/action/showPdf?pii=S0896-6273%2817%2930512-3 (1) - Review
https://www.nature.com/articles/nn.2739 (2)
https://www.jci.org/articles/view/46229 (3)
https://www.nature.com/articles/s41586-021-03299-4 (4)
https://www.sciencedirect.com/science/article/pii/S0092867415000768?via%3Dihub (5)
https://elifesciences.org/articles/46348 (6)
https://pubmed.ncbi.nlm.nih.gov/24567905/ (7)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298648/ (8)