Talk:Immunocompetence

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Wrong ref

Content not supported by ref, but the editor who added it reverted a revert: "In order for lymphocytes such as T cells to become immunocompetent, which is referring to the ability of lymphocyte cell receptors to recognize MHC molecules, they must undergo positive selection via self-peptides ^[1]."

References

^ Pillai. (2004). Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunological Reviews., 197(1), 206–218. https://doi.org/10.1111/j.0105-2896.2003.097.x

Text removed from article (on the subject of immunoINcompetence)

Examples include:

a newborn who does not yet have a fully functioning immune system but may have maternally transmitted antibodies – immunodeficient;
a late stage AIDS patient with a failed or failing immune system – immuno-incompetent; or
a transplant recipient taking medication so their body will not reject the donated organ – immunocompromised.

There may be cases of overlap but these terms all describe immune system not fully functioning.

The US Centers for Disease Control and Prevention (CDC) recommends that household and other close contacts of persons with altered immunocompetence receive the MMR, varicella, and rotavirus vaccines according to the standard schedule of vaccines, as well as receiving an annual flu shot. All other vaccines may be administered to contacts without alteration to the vaccine schedule, with the exception of the smallpox vaccine. Persons with altered immunocompetence should not receive live, attenuated vaccines (viral or bacterial), and may not receive the full benefit of inactivated vaccines.^[1] Cerulean Depths (talk) 15:45, 17 October 2024 (UTC)[reply]

^ "ACIP Altered Immunocompetence Guidelines for Immunizations". The Centers for Disease Control and Prevention. 14 September 2018. Retrieved 9 October 2018.

[1] Pillai. (2004). Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunological Reviews., 197(1), 206–218. https://doi.org/10.1111/j.0105-2896.2003.097.x

[CDC_2017-2] "ACIP Altered Immunocompetence Guidelines for Immunizations". The Centers for Disease Control and Prevention. 14 September 2018. Retrieved 9 October 2018.

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