Talk:Equianalgesic

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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Ndinhsum.

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Oral vs intramuscular morphine

I cannot find reliable Equianalgesic tables that use 10mg oral morphine as the base. They seem to mostly use 10mg IM morphine. Should we switch to that base to accurately source this page? It looks like this chart was straight copied from http://www.pharmer.org/forum/discussion-prescription-and-otc-meds/opioid-comparison The Irish Intinian (talk) 01:27, 22 December 2011 (UTC)[reply]

The chart is in desperate need of some reliable sources. If more sources can be found for the 10 mg IM morphine base, I'd support it. The table should really be rebuilt from scratch in that case and each compound, or parameter of the compound, referenced to some article/table. – Acdx (talk) 03:41, 14 January 2012 (UTC)[reply]

The values definitely need to be verified from top to bottom. Ideally, the chart should cover intravenous, oral, subcutaneous, sublingual, and transdermal routes, with the most common reference as a default baseline. — C M B J 11:15, 20 May 2013 (UTC)[reply]

It shouldn't be too difficult to do that, since the charts are all over the web. Here's one. ISBN 9781585282975 appears to be a book on the subject; table 1-1 (p. 5) covers a lot of it. Table 42-1 (p. 523) in ISBN 9780849309267 covers routes of administration for more than a dozen drugs. WhatamIdoing (talk) 00:26, 4 February 2014 (UTC)[reply]

Acetaminophen IV vs Opiates

The reference only shows the reduction in pain score as rated by the patient after 60 minutes is comparable. I think this direct extrapolation of pain score to equivalent dose is original research, and dubious at that. For example this source http://www.drugs.com/pro/diflunisal.html compares 1000mg diflunisal to 600mg acetaminophen + 60mg codeine. This would put acetaminophen at 1/2400 the strength of oral morphine. Since this is a difference of 100 times, I will remove acetaminophen from the list until I find more conclusive sources. IrregularPoster (talk) 19:51, 25 September 2013 (UTC)[reply]

Morphine IV vs Morphine PO

Since Morphine IV is shown as 3 times stronger than Morphine PO, shouldn't the bio-availability of the morphine PO calculated as 33%?(assuming all other variants are held the same, such as cross tolerance and etc, which there was no indication to think otherwise on the chart.)

TY — Preceding unsigned comment added by 212.253.113.88 (talk) 09:00, 27 August 2014 (UTC)[reply]

Oxymorphone vs. morphine

If oral oxymorphone is 7 times stronger than oral morphine, how can 3.33 mg of oxymorphone be equivalent to 10 mg of morphine? I think an error has been made.66.249.82.173 (talk) 11:42, 4 December 2014 (UTC) It says 1mg IV (intravenously) if you look further to the right on that line — Preceding unsigned comment added by Patek Bozz (talk • contribs) 11:25, 17 October 2017 (UTC)[reply]

https://en.wikipedia.org/wiki/Dihydroetorphine

It says it's used in China, seemingly widely. But on this page of comparisons it lists this as an animal tranquilizer and not used in human medicine. Which one is it? — Preceding unsigned comment added by 71.211.140.82 (talk) 03:29, 27 October 2015 (UTC)[reply]

Dihydroetorphine potency-dose conflict

How can dihydroetorphine be more potent than etorphine, yet have a larger equivalent dose? As potency grows, the equivalent dose shrinks. Based on etorphine's equivalent dose of 3.3–10 μg, dihydroetorphine's eq dose should be 0.83–10 μg not 20–40 µg. 20–40 µg doesn't make sense. — βox73 (৳alk) 08:50, 7 January 2017 (UTC) 22:18, 8 January 2017 (UTC) βox73 (৳alk) 22:19, 8 January 2017 (UTC)[reply]

Adding common non-pain, opioid interacting meds

Having Eluxadoline, diphenoxylate, loperamide, dextromethorphan, ketamine, octreotide, oripavine, phencyclidine (PCP), and/or Kratom would be nice if anyone wanted to add those. — Preceding unsigned comment added by Aglo123 (talk • contribs) 23:22, 12 January 2017 (UTC)[reply]

Wrong equivalence for codeine and tramadol

Somehow the equivalence for codeine and tramadol is wrong it should be 10mg morphine = 100 mg codeine = 100 mg tramadol 49.207.48.23 (talk) 11:19, 15 March 2017 (UTC)[reply]

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Merge proposal

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

The result of this discussion was to revert the premature merge and to NOT merge the two pages.―Biochemistry🙴❤ 05:21, 20 November 2017 (UTC)[reply]

Hi, I would like to merge this article under Opioid rotation since that is the primary purpose of Equianalgesic (Ndinhsum (talk) 03:44, 1 November 2017 (UTC))[reply]

Oppose. There are many reasons that one may wish to employ an equianalgesic chart, other than to "improve pain control or reduce unwanted side effects" (as stated in Opioid rotation). See Equianalgesic#purpose. ―Biochemistry🙴❤ 02:48, 3 November 2017 (UTC)[reply]

Understood. Thank you for your feedback. (Ndinhsum (talk) 16:52, 7 November 2017 (UTC))[reply]

Oppose this merge was premature, not adequately discussed and should be reversed. Opioid rotation and equianalgesic are related but distinct terms which should be dealt with in separate articles, and as the original author of the opioid rotation page I would not have supported a merge if you had not rushed ahead and done it already while I was away on holiday. Meodipt (talk) 01:28, 9 November 2017 (UTC)[reply]

Nobody has done the merge yet, so that's not a problem. --Tryptofish (talk) 21:30, 9 November 2017 (UTC)[reply]

No worries, nothing will be merged. I will make different changes to the Opioid Rotations article. (Ndinhsum (talk) 16:28, 13 November 2017 (UTC))[reply]

Meodipt and I have reverted the previously merged content from opioid rotation.―Biochemistry🙴❤ 05:21, 20 November 2017 (UTC)[reply]

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

morphine vs. oxycodone

This article (before I edited it) said that oral morphine and IV oxycodone are equianalgesic, and says that oral oxycodone is intermediate in potency between oral morphine and IV morphine; however, the table in the article on oxycodone says that IV oxycodone is about 3 times as potent as oral morphine and is equianalgesic to IV morphine.

Because any inaccuracy may be harmful, I blanked a couple of the numbers in the “oxycodone (IV)” row in this article until somebody can resolve the discrepancy. (I also moved the row down a little bit.) Bwrs (talk) 06:23, 26 January 2023 (UTC)[reply]