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Talk:Acute intermittent porphyria

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Symptoms

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From NCBI Porphyrias involve three major symptoms: -Abdominal pain or cramping (only in some forms of the disease) -Light sensitivity causing rashes, blistering, and scarring of the skin (photodermatitis) -Problems with the nervous system and muscles (seizures, mental disturbances, nerve damage)

Attacks can occur suddenly, usually with severe abdominal pain followed by vomiting and constipation. Being out in the sun can cause pain, sensations of heat, blistering, and skin redness and swelling. Blisters heal slowly, often with scarring or skin color changes. They may be disfiguring. Urine may turn red or brown after an attack. — Preceding unsigned comment added by 129.81.105.75 (talk) 20:28, 25 January 2012 (UTC)[reply]

Certain

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Certain medications can elicit an acute attack. Among these are steroids and barbiturates.

are cultural references really necessary? —Preceding unsigned comment added by 200.50.72.156 (talk) 21:44, 9 May 2008 (UTC)[reply]

Poor Language

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Much of this article needs to be rewritten. The language in parts is unfitting, for example: "Barbiturates must be avoided." This is an encyclopedia, not an instruction manual. And no source was cited for that bold statement. svadhisthana (talk) 15:30, 22 August 2008 (UTC)[reply]

Physiology

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From the article: "Under normal circumstances, heme synthesis begins in the mitochondrion, proceeds into the cytoplasm, and finishes back in the mitochondrion. However, without porphobilinogen deaminase, a necessary cytoplasmic enzyme, heme synthesis cannot finish, and the metabolite porphyrin accumulates in the cytoplasm."

Which cell mitochondria produce heme molecules? Marrow? Spleen? Skeletal Muscle? I feel pretty confident that it is not neurons, nor cells lining the pericardium. More specificity with sources is required. Aramis1250 (talk) 06:58, 1 November 2008 (UTC)[reply]

some guy talks about barbiturates

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I'm not related to the originator of this document, so I'm not able to address the lack of a proper citation. But as an AIP sufferer, I will say this: that my mother (also a sufferer) was told by her doctor, both for her edification and to pass on to me, that there are four major, common, and broad categories of drug an AIP patient "must avoid" ... Alcohol, barbiturates, steroids, and sulfates.

Considering as I said a moment ago I have no relation to the writer of this document, perhaps you can take it on my+his word that "doctors" say, or used to say, such bold things as this page says. 66.96.79.197 (talk) 03:54, 14 November 2008 (UTC)[reply]

i think the contraceptive pill is also notorious in precipitating an attack, and is in fact contraindicated. http://www.patient.co.uk/showdoc/40001619/ 78.154.194.195 (talk) 13:34, 9 March 2009 (UTC)[reply]

As a (male) sufferer of AIP in with multiple female relations, as far as I know, it is, as of now, uncertain as to whether birth control pills are a proximate cause of acute porphyric attacks in persons suffering from BLOOD porphyrias. Estrogen may be safe in the hepatic porphyrias...progesterone is the one that may not be safe in the hepatic porphyrias.Rotellam1 (talk) 02:00, 22 April 2012 (UTC)[reply]

Anastasia Romanova?

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Besides there being no citation for the fact that "Anastasia Romanova" may have had porphyria...there's two very important people in history with that name and countless notable royal Russians with the name Anastasia of Russia. Most notably, there was Anastasia Romanova, wife of Ivan the Terrible and Grand Duchess Anastasia Romanova.Rotellam1 (talk) 02:11, 22 April 2012 (UTC)[reply]

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