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Urea transporter 2

From Wikipedia, the free encyclopedia
(Redirected from SLC14A2)
SLC14A2
Identifiers
AliasesSLC14A2, HUT2, UT-A2, UT2, UTA, UTR, hUT-A6, solute carrier family 14 member 2
External IDsOMIM: 601611; MGI: 1351653; HomoloGene: 5183; GeneCards: SLC14A2; OMA:SLC14A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242692
NM_007163
NM_001371319

NM_001110273
NM_001110274
NM_030683
NM_207651

RefSeq (protein)

NP_001229621
NP_009094
NP_001358248

NP_001103743
NP_001103744
NP_109608
NP_997534

Location (UCSC)Chr 18: 45.21 – 45.68 MbChr 18: 78.19 – 78.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene.[5][6]

Function

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In mammalian cells, urea is the chief end-product of nitrogen catabolism and plays an important role in the urinary concentration mechanism. Thus, the plasma membrane of erythrocytes and some renal epithelial cells exhibit an elevated urea permeability that is mediated by highly selective urea transporters. In mammals, two urea transporters have been identified: the renal tubular urea transporter, UT2 (UT-A), and the erythrocyte urea transporter, UT11 (also called UT-B, coded for by the SLC14A1 gene).[6] SLC14A2 and SLC14A1 constitute solute carrier family 14.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132874Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024552Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P (Jul 1996). "Molecular characterization of a new urea transporter in the human kidney" (PDF). FEBS Lett. 386 (2–3): 156–60. doi:10.1016/0014-5793(96)00425-5. PMID 8647271. S2CID 13312002.
  6. ^ a b "Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.