NCAPH2

NCAPH2
Identifiers
Aliases	NCAPH2, CAPH2, non-SMC condensin II complex subunit H2
External IDs	OMIM: 611230; MGI: 1289164; HomoloGene: 12045; GeneCards: NCAPH2; OMA:NCAPH2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.33 Start 50,508,224 bp End 50,524,780 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 E3|15 44.84 cM Start 89,239,922 bp End 89,257,029 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right testis left testis ventricular zone vena cava ganglionic eminence anterior pituitary apex of heart right frontal lobe Top expressed in spermatocyte ventricular zone dentate gyrus of hippocampal formation granule cell lip blastocyst corneal stroma right kidney yolk sac superior frontal gyrus muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding chromatin binding Cellular component membrane chromosome nucleus nucleoplasm cell junction intercellular bridge condensed chromosome condensin complex Biological process chromosome condensation female meiotic nuclear division meiotic chromosome condensation T cell differentiation in thymus chromosome organization mitotic sister chromatid separation female meiosis chromosome separation mitotic chromosome condensation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29781 52683 Ensembl ENSG00000025770 ENSMUSG00000008690 UniProt Q6IBW4 Q8BSP2 RefSeq (mRNA) NM_001185011 NM_014551 NM_152299 NM_001115132 NM_001271600 NM_001271601 RefSeq (protein) NP_001171940 NP_055366 NP_689512 NP_001108604 NP_001258529 NP_001258530 Location (UCSC) Chr 22: 50.51 – 50.52 Mb Chr 15: 89.24 – 89.26 Mb PubMed search
Wikidata
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Condensin-2 complex subunit H2, also known as chromosome-associated protein H2 (CAP-H2) or non-SMC condensin II complex subunit H2 (NCAPH2), is a protein that in humans is encoded by the NCAPH2 gene. CAP-H2 is a subunit of condensin II, a large protein complex involved in chromosome condensation.

Further reading

• Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Ono T, Losada A, Hirano M, et al. (2003). "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells". Cell. 115 (1): 109–21. doi:10.1016/S0092-8674(03)00724-4. PMID 14532007.
• Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Wood AJ, Severson AF, Meyer BJ (2010). "Condensin and cohesin complexity: the expanding repertoire of functions". Nat. Rev. Genet. 11 (6): 391–404. doi:10.1038/nrg2794. PMC 3491780. PMID 20442714.
• Schleiffer A, Kaitna S, Maurer-Stroh S, et al. (2003). "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners". Mol. Cell. 11 (3): 571–5. doi:10.1016/S1097-2765(03)00108-4. PMID 12667442.
• Kamatani Y, Matsuda K, Okada Y, et al. (2010). "Genome-wide association study of hematological and biochemical traits in a Japanese population". Nat. Genet. 42 (3): 210–5. doi:10.1038/ng.531. PMID 20139978. S2CID 30790619.
• Collins JE, Wright CL, Edwards CA, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.