Myod family inhibitor domain containing

MDFIC
Identifiers
Aliases	MDFIC, HIC, MyoD family inhibitor domain containing, MDFIC1
External IDs	OMIM: 614511; MGI: 104611; HomoloGene: 18404; GeneCards: MDFIC; OMA:MDFIC - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	115,019,917 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	15,802,168 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; tibia; ; Epithelium of choroid plexus; ; lactiferous duct; ; skin of hip; ; visceral pleura; ; germinal epithelium; ; mucosa of paranasal sinus; ; periodontal fiber; ; oral cavity;
	Top expressed in
	Epithelium of choroid plexus; ; cumulus cell; ; epithelium of lens; ; ciliary body; ; stroma of bone marrow; ; iris; ; right lung lobe; ; choroid plexus of fourth ventricle; ; conjunctival fornix; ; calvaria;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription factor binding; Tat protein binding; protein binding; cyclin binding;
Cellular component	nucleolus; nucleus; cytoplasm; Golgi apparatus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; positive regulation of viral transcription; regulation of Wnt signaling pathway; viral process; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of protein import into nucleus; negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	29969
	16543
	ENSG00000135272
	ENSMUSG00000041390
	Q9P1T7
	Q8BX65
	NM_199072; NM_001166345; NM_001166346
	NM_175088
	NP_001159817; NP_001159818; NP_951038
	NP_780297
	Wikidata
View/Edit Human	View/Edit Mouse

MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. ^[5]

Function

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135272 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041390 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MyoD family inhibitor domain containing". Retrieved 2016-02-09.

Function

References

Further reading