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Joomyeong Kim

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Joomyeong Kim
Professor Joomyeong Kim
Born
Joomyeong Kim
NationalityAmerican / South Korean
EducationLSU Medical Center at New Orleans, LA (Ph. D.)
Seoul National University (M.S., B.S.)
Alma materLSU Medical Center at New Orleans, LA (Ph. D., 1995)
Scientific career
FieldsGenomic imprinting; Epigenetics
InstitutionsOak Ridge National Laboratory
Lawrence Livermore National Laboratory
Louisiana State University

Joomyeong Kim is a Russell Thompson, Jr. Family Professor of Biology at Louisiana State University. His research interests include genomic imprinting and epigenetics. Dr. Kim's laboratory is mainly involved in understanding the functions and regulatory mechanisms governing genes subject to genomic imprinting.[1] Having previously characterized an imprinted domain located on proximal mouse chromosome 7/ human chromosome 19q13.4, his laboratory currently focuses on understanding regulatory mechanisms directing the mono-allelic expression of the seven imprinted genes in the cluster: Peg3, Usp29, Zfp264, APeg3 (paternally expressed) and Zim1, Zim2, Zim3 (maternally expressed).[2][3][4][5][6][7][8] As a second project direction, his lab studies the function of the dominant gene in the cluster, Peg3, as a transcriptional regulator.[9][10][11][12] Past projects in the Kim lab have included studying the epigenetic instability of imprinted genes during tumorigenesis,[13][14][15] potential roles of AEBP2 as a PRC2 targeting protein and in neural crest cell development,[16][17][18] as well as the DNA methylation of mouse and human retrotransposons.[19][20]


Education

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Selected publications

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  • Kim J, Ekram MB, Kim H, Faisal M, Frey WD, Huang JM, Tran K, Kim MM, Yu S (2012). "Imprinting control region (ICR) of the Peg3 domain". Hum Mol Genet. 21 (12): 2677–87. doi:10.1093/hmg/dds092. PMC 3363340. PMID 22394678.
  • Thiaville MM, Kim H, Frey WD, Kim J (2013). "Identification of an evolutionarily conserved cis-regulatory element controlling the Peg3 imprinted domain". PLOS ONE. 8 (9): e75417. doi:10.1371/journal.pone.0075417. PMC 3769284. PMID 24040411.
  • Kim J, Frey WD, He H, Kim H, Ekram MB, Bakshi A, Faisal M, Perera BP, Ye A, Teruyama R (2013). "Peg3 mutational effects on reproduction and placenta-specific gene families". PLOS ONE. 8 (12): e83359. doi:10.1371/journal.pone.0083359. PMC 3877027. PMID 24391757.
  • Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–20. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.

References

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  1. ^ "Joomyeong Kim". Retrieved Nov 15, 2017.
  2. ^ Kim J, Ekram MB, Kim H, Faisal M, Frey WD, Huang JM, Tran K, Kim MM, Yu S (2012). "Imprinting control region (ICR) of the Peg3 domain". Hum Mol Genet. 21 (12): 2677–87. doi:10.1093/hmg/dds092. PMC 3363340. PMID 22394678.
  3. ^ Thiaville MM, Kim H, Frey WD, Kim J (2013). "Identification of an evolutionarily conserved cis-regulatory element controlling the Peg3 imprinted domain". PLOS ONE. 8 (9): e75417. doi:10.1371/journal.pone.0075417. PMC 3769284. PMID 24040411.
  4. ^ Kim J, Ye A (2016). "Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain". PLOS ONE. 11 (4): e0154216. doi:10.1371/journal.pone.0154216. PMC 4841594. PMID 27104590.
  5. ^ Perera BP, Kim J (2016). "Alternative promoters of Peg3 with maternal specificity". Sci Rep. 6: 24438. doi:10.1038/srep24438. PMC 4830991. PMID 27075691.
  6. ^ He H, Perera BP, Ye A, Kim J (2016). "Parental and sexual conflicts over the Peg3 imprinted domain". Sci Rep. 6: 38136. doi:10.1038/srep38136. PMC 128876. PMID 27901122.
  7. ^ He H, Ye A, Perera BP, Kim J (2017). "YY1's role in the Peg3 imprinted domain". Sci Rep. 7 (1): 6427. doi:10.1038/s41598-017-06817-5. PMC 5526879. PMID 28743993.
  8. ^ Bretz CL, Kim J (2017). "Transcription-driven DNA methylation setting on the mouse Peg3 locus". Epigenetics. Sep 19 [Epub ahead of print] (11): 945–952. doi:10.1080/15592294.2017.1377869. PMC 5788428. PMID 28925797.
  9. ^ Ye A, He H, Kim J (2014). "Paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor". PLOS ONE. 9 (9): e108596. doi:10.1371/journal.pone.0108596. PMC 4180786. PMID 25265264.
  10. ^ Lee S, Ye A, Kim J (2015). "DNA-Binding Motif of the Imprinted Transcription Factor PEG3". PLOS ONE. 10 (12): e0145531. doi:10.1371/journal.pone.0145531. PMC 4686966. PMID 26692216.
  11. ^ Ye A, He H, Kim J (2016). "PEG3 binds to H19-ICR as a transcriptional repressor". Epigenetics. 11 (12): 889–900. doi:10.1080/15592294.2016.1255385. PMC 5193492. PMID 27824289.
  12. ^ Ye A, He H, Kim J (2017). "PEG3 control on the mammalian MSL complex". PLOS ONE. 12 (6): e0178363. doi:10.1371/journal.pone.0178363. PMC 5469463. PMID 28609438.
  13. ^ Kim J, Bretz CL, Lee S (2015). "Epigenetic instability of imprinted genes in human cancers". Nucleic Acids Res. 43 (22): 10689–99. doi:10.1093/nar/gkv867. PMC 4678850. PMID 26338779.
  14. ^ Bretz CL, Langohr IM, Lee S, Kim J (2015). "Epigenetic instability at imprinting control regions in a Kras(G12D)-induced T-cell neoplasm". Epigenetics. 10 (12): 1111–201. doi:10.1080/15592294.2015.1110672. PMC 4844204. PMID 26507119.
  15. ^ Bretz CL, Langohr IM, Kim J (2017). "Epigenetic response of imprinted domains during carcinogenesis". Clin Epigenetics. 9: 90. doi:10.1186/s13148-017-0393-8. PMC 5572065. PMID 28855972.
  16. ^ Kim H, Kang K, Kim J (2009). "AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2". Nucleic Acids Res. 37 (9): 2940–50. doi:10.1093/nar/gkp149. PMC 2685092. PMID 19293275.
  17. ^ Kim H, Kang K, Ekram MB, Roh TY, Kim J (2011). "Aebp2 as an epigenetic regulator for neural crest cells". PLOS ONE. 6 (9): e25174. doi:10.1371/journal.pone.0025174. PMC 3176318. PMID 21949878.
  18. ^ Kim H, Ekram MB, Bakshi A, Kim J (2015). "AEBP2 as a transcriptional activator and its role in cell migration". Genomics. 105 (2): 108–15. doi:10.1016/j.ygeno.2014.11.007. PMC 4314425. PMID 25451679.
  19. ^ Bakshi A, Kim J (2014). "Retrotransposon-based profiling of mammalian epigenomes: DNA methylation of IAP LTRs in embryonic stem, somatic and cancer cells". Genomics. 104 (6): 538–44. doi:10.1016/j.ygeno.2014.09.009. PMC 4262695. PMID 25277721.
  20. ^ Bakshi A, Herke SW, Batzer MA, Kim J (2016). "ADNA methylation variation of human-specific Alu repeats". Epigenetics. 11 (2): 163–73. doi:10.1080/15592294.2015.1130518. PMC 4846114. PMID 26890526.
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