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HLA-B55

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major histocompatibility complex (human), class I, B55
Alleles B*5501, B*5502
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5501
B*5502
Locus chr.6 6p21.31

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.[1] (For terminology help see: HLA-serotype tutorial)

Serotype

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B*55:03 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*18:06, B*46:01, and B*73:01.[2]

B55 and B22 serotype recognition of some HLA B*55 allele-group gene products[3]
B*55 B55 B22 Sample
allele % % size (N)
5501 92 5 453
5502 84 2 309

Allele distribution

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HLA B*5501 frequencies
freq
ref. Population (%)
[4] India New Delhi 3.8
[4] Singapore Chinese Han 3.5
[4] Spain Eastern Andalusia Gipsy 3.5
[4] Georgia Tbilisi Kurds 3.4
[4] India North Delhi 3.3
[4] France South East 3.1
[4] Israel Arab Druse 3.0
[4] India North Hindus 2.9
[4] Georgia Tbilisi Georgians 2.8
[4] Russia Tuva (2) 2.8
[4] Georgia Svaneti Svans 2.5
[4] Iran Baloch 2.5
[4] Singapore Thai 2.5
[4] Sudanese 2.5
[4] Mexico Mestizos 2.4
[4] Spain Eastern Andalusia 2.4
[4] Ireland South 2.0
[4] Azores Central Islands 1.8
[4] Bulgaria 1.8
[4] Israel Ashkenazi and Non Ashkenazi Jews 1.8
[4] Oman 1.7
[4] Tunisia Tunis 1.7
[4] India Andhra Pradesh Golla 1.4
[4] China Tibet 1.3
[4] Uganda Kampala 1.2
[4] Finland 1.1
[4] Portugal North 1.1
[4] Portugal Centre 1.0
[4] Singapore Riau Malay 1.0
[4] B*5502
[4] Taiwan Taroko 14.5
[4] American Samoa 12.0
[4] China Guangxi Maonan 6.0
[4] Japan Ainu Hokkaido 5.0
[4] China Tibet Autonomous Region Tibetans 4.7
[4] Singapore Chinese 3.0
[4] China Beijing Shijiazhuang Tianjian Han 2.9
[4] China North Han 2.9
[4] South Korea (3) 2.7
[4] Hong Kong Chinese 2.2
[4] Japan (5) 2.2
[4] Taiwan Ami 2.0
[4] Thailand (3) 2.0
[4] New Caledonia 1.0
[4] Philippines Ivatan 1.0

References

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  1. ^ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ^ Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.
  3. ^ derived from IMGT/HLA
  4. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.